Pharmacology of HIV integrase inhibitors. [PDF]
Curr Opin HIV AIDS, 2012 Purpose of reviewThe purpose of this study is to review recent and relevant pharmacology data for three HIV integrase inhibitors: raltegravir (marketed), dolutegravir, and elvitegravir (both in phase III drug development).
Adams JL, Greener BN, Kashuba AD.
europepmc +8 more sources
Update on Adverse Effects of HIV Integrase Inhibitors. [PDF]
Curr Treat Options Infect Dis, 2019 The goal of this paper is to provide an up-to-date review of adverse events related to the class of integrase strand transfer inhibitors (INSTIs), which became the class of choice in few years.
Kolakowska A +3 more
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HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses [PDF]
mBio, 2014 The catalytic site of the HIV integrase is contained within an RNase H-like fold, and numerous drugs have been developed that bind to this site and inhibit its activity.
Zhipeng Yan +8 more
doaj +3 more sources
Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps. [PDF]
Clin Pharmacokinet, 2019 Prevention of mother-to-child transmission of HIV and optimal maternal treatment are the most important goals of antiretroviral therapy in pregnant women with HIV.
van der Galiën R +6 more
europepmc +2 more sources
Resistance to HIV Integrase Inhibitors: About R263K and E157Q Mutations. [PDF]
Viruses, 2018 The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance.
Charpentier C, Descamps D.
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HIV Dynamics and Integrase Inhibitors [PDF]
Antiviral Chemistry and Chemotherapy, 2009 The integrase inhibitor (INI) raltegravir has shown promising results in clinical trials to date, reducing second phase HIV RNA levels by 70% in comparison with standard regimens. These trial results have been limited by the 50 copies/ml detection limit of the HIV RNA assay and have not investigated the effect of an INI regimen on levels of latently ...
John M. Murray
openalex +4 more sources
HIV integrase inhibitors: 20-year landmark and challenges.
Advances in Pharmacology, 2013 n ...
M. Métifiot, C. Marchand, Y. Pommier
semanticscholar +4 more sources
HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play? [PDF]
European Journal of Medical Research, 2009 End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined.
Vogel Martin, Nelson Mark
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Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2 [PDF]
VirusesRetroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie +6 more
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Biomath, 2012 Antiviral combination therapies consisting of reverse transcriptase inhibitors, protease inhibitors and an integrase inhibitor, have been developed to suppress HIV below the limit of detection.
Dimitra Bon +3 more
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