Results 111 to 120 of about 17,322 (222)

Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes. [PDF]

Cells, 2022
Ngono Ayissi K, Gorwood J, Le Pelletier L, Bourgeois C, Beaupère C, Auclair M, Foresti R, Motterlini R, Atlan M, Barrail-Tran A, Le Grand R, Desjardins D, Fève B, Lambotte O, Capeau J, Béréziat V, Lagathu C.   +16 more
europepmc   +1 more source

Brief Histories of Retroviral Integration Research and Associated International Conferences

Viruses
The field of retroviral integration research has a long history that started with the provirus hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase enzymes.
Duane P. Grandgenett, Alan N. Engelman
doaj   +1 more source

Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan

Scientific Reports
HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in ...
Chien-An Tu, Chien-Feng Kuo, Chun-Ming Lee, Chang-Pan Liu, Hsiang-Kuang Tseng, Tseng-Yu Huang, Chih-Chen Lin, Hsun Chang, Winter Yu-Ning Lee, Fang-Ju Sun, Zu-Yi Sun, Pei-Ching Lian, Ming-Wei Cheng, Alice Ying-Jung Wu   +13 more
doaj   +1 more source

Peptide inhibitors of HIV -1 integrase activity and dimerization

, 2005
Protein-protein interactions are increasingly being studied as targets for therapeutic intervention of many biological processes. However, the design of agents to disrupt these biologically important interactions is still in its infancy.
Zhao, Lei
core  

Integrase strand transfer inhibitors (INSTIS) resistance mutations in HIV-1 infected Turkish patients

, 2016
Objectives: Integrase strand transfer inhibitor (INSTI) is a new class of antiretroviral (ARV) drugs designed to block the action of the integrase viral enzyme, which is responsible for insertation of the HIV-1 genome into the host DNA.
Sayan, M., Özgür, G., Sargın, F., Gündüz, A., İnan, A., Deveci, A., Ersöz, G.   +6 more
core   +1 more source

Napthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation

, 2008
HIV-1 integrase is an important target for the identification of novel antiretroviral compounds potentially active against HIV-1 replication. Previously, we discovered several novel thiazolothiazepine derivatives as IN inhibitors with antiviral activity ...
Brizzi A., Aiello F., Garofalo A., Dayam R., Grande F., Neamati N.   +5 more
core   +1 more source

Synthesis of new potential HIV-1 integrase inhibitors

, 2004
A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3(hetero)aryl substituted 3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported.
Ferro, S., Rao, A., Barreca, M.L., Debyser, Zeger, Chimirri, A., Zappala, M., Monforte, P., Witvrouw, Myriam   +7 more
core   +1 more source

Challenging the HIV DNA integration dogma:Integration-independent HIV replication to escape from integrase inhibitors [PDF]

Like other retroviruses, human immunodeficiency virus (HIV) has an RNA genome that is converted into a linear DNA molecule upon infecting host cells. This viral DNA is then integrated into the host’s cellular DNA by the viral integrase and subsequently ...
Dekker, J.G.
core   +2 more sources

Molecular modelling for a series of integrase HIV-I inhibitors

, 2011
Uma etapa essencial no ciclo de vida do vírus HIV é a integração do DNA viral no cromossomo hospedeiro. Essa etapa é catalisada pela enzima integrase (IN) de 32-kDa. HIV-1 IN é um importante e validado alvo, e as drogas que inibem seletivamente a enzima,
Luciana Luzia de Carvalho, Carvalho, Luciana Luzia de   +1 more
core   +1 more source

Isolation of New Chemical Modulators of the Interaction Between HIV-1 Integrase and the Cellular Restriction Factor GCN2

Viruses
Integrase is a key protein during HIV-1 replication as it catalyzes the integration of viral DNA into the host DNA. After several decades of research, highly potent and selective active site inhibitors have emerged.
Chloé Torres, Floriane Lagadec, Eugenia Basyuk, Patricia Recordon-Pinson, Mathieu Métifiot   +4 more
doaj   +1 more source