Results 121 to 130 of about 17,322 (222)

Innate sensing of HIV-infected cells

, 2011
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells.
Richard E. Randall, Randall, Richard E, Mustapha Si-Tahar, Helen K W Law, Julien Pothlichet, Plumas, Joel, Lepelley, Alice, Mammano, Fabrizio, Helen K. W. Law, Richard E Randall, Schwartz, Olivier, Albert, Matthew L, Albert, Matthew L., Louis, Stephanie, Laurence Chaperot, Chaperot, Laurence, Stéphanie Louis, Pothlichet, Julien, Olivier Schwartz, Si-Tahar, Mustapha, Sourisseau, Marion, Schilte, Clementine, Law, Helen K. W., Law, Helen K W, Marion Sourisseau, Joël Plumas, Alice Lepelley, Clémentine Schilte, Fabrizio Mammano, Matthew L Albert, Matthew L. Albert, Randall, Richard Edward   +31 more
core   +1 more source

Critical appraisal of elvitegravir in the treatment of HIV-1/AIDS

HIV/AIDS: Research and Palliative Care, 2014
Krishan K PandeyInstitute for Molecular Virology, Saint Louis University Health Sciences Center, St Louis, MO, USAAbstract: Human immunodeficiency virus type 1 (HIV-1) integrase inhibitors belong to a novel class of antiretroviral drugs with high potency
Pandey KK
doaj  

From protease inhibitors to integrase strand transfer inhibitors: the evolution of HIV drug resistance management

Zhongguo linchuang yanjiu
Antiretroviral therapy (ART) has significantly improved the prognosis of HIV/AIDS patients and has become an important global strategy for the prevention and control of AIDS.
HU Zhiliang, YANG Yongfeng
doaj   +1 more source

Possible pharmacological target for inhibition of HIV integration

, 2023
The treatment of HIV/AIDS involves the use of multiple antiretroviral drugs categorized into six major classes that target different stages of the HIV life cycle.
Tokimitsu, Shigeki
core  

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

, 2004
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new mechanisms of action.
Stillmock, Espeseth, Summa V, Huff, J R., Ellis, Pearson, N J., Grobler, PG., Zhuang, Wong, Guare, Xu, Holloway, D J., Embrey, K A., Kassahun, J D., WA., JP., Witmer, Egbertson, Jolly, Miller, S D, AS., Wai, M D., Vacca, Felock, Cortese, E, Gomez, Jr., S M., R P., J, K, L, M, M S., Chen, Schleif, M. K, R, I-W, Fisher, J P., W, J H., Danovich, Young, Emini, Anthony, M V., Jin, Lin, J S., T E., PJ., Hazuda, B K.   +63 more
core   +1 more source

Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors

, 2013
The quinolone HL1 and the hydroxypyrimidine-carboxamide HL2 were designed and synthesized as models of the HIV integrase strand transfer inhibitors Elvitegravir and Raltegravir (brand name Isentress), with the aim to study their complexing behavior and ...
Bacchi, Alessia, Sechi, Mario, Neamati, Nouri, M. Sechi, T. W. Sanchez, N. Neamati, G. Rispoli, Rogolino, Dominga, Carcelli, Mauro, Pelagatti, Paolo, Sanchez, Tino W., Rispoli, Gabriele   +11 more
core   +1 more source

Binding Mode Prediction of Strand Transfer HIV-1 Integrase Inhibitors Using Tn5 Transposase as a Plausible Surrogate Model for HIV-1 Integrase

, 2016
The crystal structure of Tn5 transposase−DNA complex was used in docking experiments to predict binding modes of HIV-1 integrase strand transfer inhibitors (INSTIs).
Alba Chimirri (76729), Nunzio Iraci (148416), Laura De Luca (76726), Maria Letizia Barreca (76727)   +3 more
core   +1 more source

HIV Integrase Inhibitor [PDF]

, 2020
openaire   +1 more source

Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps. [PDF]

Clin Pharmacokinet, 2019
van der Galiën R, Ter Heine R, Greupink R, Schalkwijk SJ, van Herwaarden AE, Colbers A, Burger DM.   +6 more
europepmc   +1 more source

Resistance to HIV Integrase Inhibitors: About R263K and E157Q Mutations. [PDF]

Viruses, 2018
Charpentier C, Descamps D.
europepmc   +1 more source