Results 21 to 30 of about 71,892 (273)

Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium

HIV Medicine, 2022
To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)‐based antiretroviral therapy (ART) versus non‐nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors ...
D. Byonanebye, M. Polizzotto, B. Neesgaard, M. Sarcletti, R. Matulionytė, D. Braun, A. Castagna, S. De Wit, F. Wit, E. Fontas, J. Vehreschild, J. Vesterbacka, L. Greenberg, C. Hatleberg, H. Garges, J. Gallant, A. Volny Anne, Angela Öllinger, I. Mozer‐Lisewska, Bernard Surial, V. Spagnuolo, C. Necsoi, M. van der Valk, A. Mocroft, M. Law, L. Ryom, K. Petoumenos   +26 more
semanticscholar   +1 more source

A little less aggregation a little more replication: Viral manipulation of stress granules

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley   +1 more source

Prevalence of potential drug-drug interactions in patients of the Swiss HIV Cohort Study in the era of HIV integrase inhibitors.

Clinical Infectious Diseases, 2020
BACKGROUND Prevalence of potential drug-drug interactions (PDDIs) between antiretroviral drugs (ARVs) and comedications was high in 2008 in a Swiss HIV Cohort Study (SHCS) survey.
Elisabeth Deutschmann, H. Bucher, Steffen Jaeckel, S. Gibbons, K. McAllister, A. Scherrer, D. Braun, M. Cavassini, A. Hachfeld, A. Calmy, M. Battegay, M. Cipriani, L. Elzi, James B. Young, B. López-Centeno, J. Berenguer, S. Khoo, G. Moffa, C. Marzolini   +18 more
semanticscholar   +1 more source

Three main mutational pathways in HIV-2 lead to high-level raltegravir and elvitegravir resistance: implications for emerging HIV-2 treatment regimens. [PDF]

PLoS ONE, 2012
Human immunodeficiency virus type 2 (HIV-2) is intrinsically resistant to non-nucleoside reverse transcriptase inhibitors and exhibits reduced susceptibility to several of the protease inhibitors used for antiretroviral therapy of HIV-1. Thus, there is a
Robert A Smith, Dana N Raugi, Charlotte Pan, Matthew Coyne, Alexandra Hernandez, Brad Church, Kara Parker, James I Mullins, Papa Salif Sow, Geoffrey S Gottlieb, University of Washington-Dakar HIV-2 Study Group   +10 more
doaj   +1 more source

Integrase Strand Transfer Inhibitors are Associated with Incident Diabetes Mellitus in People with HIV.

Clinical Infectious Diseases, 2022
BACKGROUND Integrase strand transfer inhibitors (INSTIs) are associated with weight gain in people with HIV (PWH). Less is known about the risk of other metabolic outcomes such as diabetes mellitus and hyperglycemia.
Jane A. O’Halloran, John M. Sahrmann, Luis Parra-Rodriguez, D. Vo, A. Butler, M. Olsen, W. Powderly   +6 more
semanticscholar   +1 more source

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design. [PDF]

PLoS ONE, 2012
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to the lens epithelium derived growth factor (LEDGF) binding site of the integrase catalytic core domain.
Thomas S Peat, David I Rhodes, Nick Vandegraaff, Giang Le, Jessica A Smith, Lisa J Clark, Eric D Jones, Jonathan A V Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H Ryan, G Paul Savage, Craig L Francis, John J Deadman   +15 more
doaj   +1 more source

Materials Discovery with Extreme Properties via Reinforcement Learning-Guided Combinatorial Chemistry [PDF]

Chemical Science, 2024, 2023
The goal of most materials discovery is to discover materials that are superior to those currently known. Fundamentally, this is close to extrapolation, which is a weak point for most machine learning models that learn the probability distribution of data.
arxiv   +1 more source

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

Viruses, 2021
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN).
Steven J. Smith, Andrea Ferris, Xuezhi Zhao, Gary Pauly, Joel P. Schneider, Terrence R. Burke, Stephen H. Hughes   +6 more
doaj   +1 more source

Folding molecular dynamics simulation of T-peptide, a HIV viral entry inhibitor : Structure, dynamics, and comparison with the experimental data [PDF]

, 2021
Peptide T is a synthetic octapeptide fragment, which corresponds to the region 185-192 of the gp120 HIV coat protein and functions as a viral entry inhibitor. In this work, a folding molecular dynamics simulation of peptide T in a membrane-mimicking (DMSO) solution was performed with the aim of characterizing the peptide's structural and dynamical ...
arxiv   +1 more source

Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs

Viruses, 2021
Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for resistant viruses.
Steven J. Smith, X. Zhao, D. Passos, D. Lyumkis, T. Burke, S. Hughes   +5 more
semanticscholar   +1 more source