Results 121 to 130 of about 651,532 (328)

2896. Oral PrEP Uptake among HVTN 704/HPTN 085 Participants: Implications for the Future of Biomedical HIV Prevention Trials [PDF]

, 2023
Valeria D Cantos, Moni B. Neradilek, Kevin Gillespie, Yunda Huang, Allan C. deCamp, Shelly Karuna, Srilatha Edupuganti, Carlos del Rı́o, Valdiléa G. Veloso, Myron S. Cohen, Deborah Donnell, Lawrence Corey, Alison C. Roxby, Colleen F. Kelley   +13 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Factors associated with voluntary HIV counseling and testing among young students engaging in casual sexual activity: a cross-sectional study from Eastern China

BMC Public Health
Objectives To investigate the factors associated with voluntary HIV counseling and testing (VCT) among young students engaging in casual sexual activity and to establish a scientific rationale for developing targeted intervention strategies for ...
Zhongrong Yang, Wanjun Chen, Weiyong Chen, Qiaoqin Ma, Hui Wang, Tingting Jiang, Meihua Jin, Xin Zhou   +7 more
doaj   +1 more source

Sexual Education- Reassessing HIV prevention policies on an international level: Review [PDF]

, 2023
MYRTO PATAGIA BAKARAKI, Panagiotis Giannakos   +1 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, EarlyView.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

The effects of HIV self-testing on HIV incidence and awareness of status among men who have sex with men in the United States: Insights from a novel compartmental model

Epidemics
Background: The OraQuick In-Home HIV self-test represents a fast, inexpensive, and convenient method for users to assess their HIV status. If integrated thoughtfully into existing testing practices, accompanied by efficient pathways to formal diagnosis ...
Alex Viguerie, Chaitra Gopalappa, Cynthia M. Lyles, Paul G. Farnham   +3 more
doaj   +1 more source

Bending the HIV epidemic curve: can prevention cascades show us how? [PDF]

, 2023
Rashida A. Ferrand, Katharina Kranzer
openalex   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, EarlyView.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Impact of detection rate and preventive treatment of latent tuberculosis infection on the future burden of tuberculosis among students in shanghai: a predictive study using Markov modeling

BMC Public Health
Background Students represent a key demographic for tuberculosis (TB) control in China. This study utilizes a dynamic Markov model to forecast the epidemiological trends of active tuberculosis (ATB) among students in Shanghai through 2035 and evaluate ...
Xiao Xiao, Zhipeng Li, Jing Chen, Xin Shen   +3 more
doaj   +1 more source