Results 31 to 40 of about 629,767 (276)

SHIV remission in macaques with early treatment initiation and ultra long-lasting antiviral activity

Nature Communications
Studies in SIV-infected macaques show that the virus reservoir is particularly refractory to conventional suppressive antiretroviral therapy (ART). We posit that optimized ART regimens designed to have robust penetration in tissue reservoirs and long ...
Michele B. Daly, Chuong Dinh, Angela Holder, Donna Rudolph, Susan Ruone, Alison Swaims-Kohlmeier, George Khalil, Sunita Sharma, James Mitchell, Jillian Condrey, Daniel Kim, Yi Pan, Kelly Curtis, Peter Williams, William Spreen, Walid Heneine, J. Gerardo García-Lerma   +16 more
doaj   +1 more source

Preclinical evaluation of long-acting cabotegravir and rilpivirine for HIV post-exposure prophylaxis in a macaque modelResearch in context

EBioMedicine
Summary: Background: Current guidelines for post-exposure prophylaxis (PEP) recommend 28 days of daily oral antiretroviral drugs. However, low adherence and inadequate regimen completion represent important challenges.
Priya Srinivasan, Jining Zhang, Tiancheng Edwards, Chuong Dinh, Ayanna Green, Dawn Little, Tyana Singletary, Maria Mendoza, Yi Pan, Frank Deyounks, Ryan Johnson, Jonathan Lipscomb, Athena P. Kourtis, Walid Heneine, J. Gerardo García-Lerma, James M. Smith   +15 more
doaj   +1 more source

Smarter Programming of the Female Condom: Increasing Its Impact on HIV Prevention in the Developing World [PDF]

, 2008
The purpose of this study was to investigate the relative value of the female condom for HIV prevention within heterosexual relationships in the developing world.
Elliot Marseille, James G. Kahn, Kyle Peterson, Laura Herman   +3 more
core  

SimpactCyan 1.0 : an open-source simulator for individual-based models in HIV epidemiology with R and Python interfaces [PDF]

, 2019
SimpactCyan is an open-source simulator for individual-based models in HIV epidemiology. Its core algorithm is written in C++ for computational efficiency, while the R and Python interfaces aim to make the tool accessible to the fast-growing community of
Delva, Wim, Hendrickx, Diana M, Hens, Niel, Kuylen, Elise, Liesenborgs, Jori, Niyukuri, David   +5 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Designing Primary Prevention for People Living with HIV [PDF]

, 2000
Today, there are new reasons for a sharper focus on prevention for people living with HIV. Growing numbers of people with the disease are living more healthy, sexual lives.
Chris Collins, Michael D. Shriver, Stephen F. Morin, Thomas J. Coates   +3 more
core  

Risky Behaviours Among Young People Living with HIV Attending Care and Treatment Clinics in Dar Es Salaam, Tanzania: Implications for Prevention with a Positive Approach. [PDF]

, 2013
Introduction: Prevention with a positive approach has been advocated as one of the main strategies to reduce new instances of HIV infection. Risky sexual behaviours among people living with HIV/AIDS are the cornerstone for this approach.
Leyna, Germana H, Mhalu, Aisa, Mmbaga, Elia J   +2 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Recent US Centers for Disease Control and Prevention Activities to Reduce HIV Stigma

Journal of the International Association of Providers of AIDS Care, 2019
HIV stigma affects many persons living with HIV in the United States, and reducing stigma is central to the US Centers for Disease Control and Prevention’s (CDC) mission to promote health and prevent HIV transmission.
Linda Beer PhD, Donna Hubbard McCree PhD, MPH, RPh, William L. Jeffries PhD, MPH, MA, Ansley Lemons MPH, Catlainn Sionean PhD   +4 more
doaj   +1 more source