Results 51 to 60 of about 2,187,766 (310)

Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé

BMC Research Notes, 2019
Objective Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia ...
Alex Durand Nka, Samuel Martin Sosso, Joseph Fokam, Yagai Bouba, Georges Teto, Rachel Simo Rachel, Aline Tiga, Junie Yimga, Elias Nchiwan Nukenine, Aubin Joseph Nanfack, Désiré Takou, Zélateur Aroga, Vittorio Colizzi, Alexis Ndjolo   +13 more
doaj   +1 more source

Advancing HIV Prevention: New Strategies for a Changing Epidemic [PDF]

Since the first cases of HIV/AIDS were recognized in 1981, the Centers for Disease Control and Prevention (CDC) and its partners have worked to combat the epidemic. Our goal has always been to stop transmission and reduce the burden of HIV/AIDS.

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Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Investigation of HIV Incidence Rates in a High-Risk, High-Prevalence Kenyan Population

Journal of the International Association of Providers of AIDS Care, 2016
Cost-effective HIV prevention programs should target persons at high risk of HIV acquisition. We conducted an observational HIV incidence cohort study in Kisumu, Kenya, where HIV prevalence is triple that of the national rate.
Rennatus Mdodo DrPH, MS, Deborah Gust PhD, Fredrick O. Otieno DCMS, MPH, Eleanor McLellan-Lemal MA, Robert T. Chen MD, MA, Charles LeBaron MD, Felicia Hardnett MS, Kyle Turner MS, Richard Ndivo BSc, Clement Zeh PhD, Taraz Samandari MD, PhD, Lisa A. Mills MD   +11 more
doaj   +1 more source

Advancing HIV Prevention progress summary April 2003-September 2005 [PDF]

On April 17, 2003, the Centers for Disease Control and Prevention (CDC) announced a new initiative, \u201cAdvancing HIV Prevention (AHP): New Strategies for a Changing Epidemic.\u201d Its aim is to reduce barriers to early diagnosis of HIV infection and ...

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METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

National HIV Prevention progress report, 2015 [PDF]

Reaching our nation\ue2\u20ac\u2122s HIV prevention goals is essential for protecting and improving the health of all people who are at risk for or living with HIV infection.

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Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

A cross-sectional analysis of fingerstick blood self-microcollection for remote HIV suppression monitoring in Atlanta, Georgia, USA: a path to expanding access to continuum of care

AIDS Research and Therapy
Background Many people with HIV experience considerable barriers to accessing HIV clinic services. Options that would permit blood sampling that preclude the need for in-clinic visits and increase privacy would aid in overcoming many of the obstacles ...
Jeffrey A. Johnson, Amanda J. Smith, Ruth Dana, Erin Rogers, M. Leanne Ward, Ariana S. Tino, Vickie Sullivan, Wei Luo, Jin-fen Li, Patrick S. Sullivan   +9 more
doaj   +1 more source