Results 61 to 70 of about 2,320,248 (308)

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Advancing HIV Prevention progress summary April 2003-September 2005 [PDF]

On April 17, 2003, the Centers for Disease Control and Prevention (CDC) announced a new initiative, \u201cAdvancing HIV Prevention (AHP): New Strategies for a Changing Epidemic.\u201d Its aim is to reduce barriers to early diagnosis of HIV infection and ...

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LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Marburg Virus Disease Surveillance in the Community Through Active Case Finding in Rwanda, 2024

International Journal of Infectious Diseases
Background: Marburg Virus Disease (MVD) is a high-threat pathogen with a high case fatality rate and rapid human-to-human transmission, posing serious public health risks.
Frederic Ntirenganya, Edouard Ruseesa, Olivier Nsekuye, Noella Benemariya, Bruce Rwagitinywa, Aphrodis Hagabimana, Hugues Valois Mucunguzi, Edson Rwagasore   +7 more
doaj   +1 more source

National HIV Prevention progress report, 2015 [PDF]

Reaching our nation\ue2\u20ac\u2122s HIV prevention goals is essential for protecting and improving the health of all people who are at risk for or living with HIV infection.

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B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Application Value of In-House HIV-1 DNA Genotypic Resistance Testing for Individuals with Low-Level Viremia

Viruses
Background: To provide evidence for HIV-1 DNA genotypic resistance testing (GRT) strategies in low-level viremia (LLV) populations by comparing the amplification efficiency and resistance mutation profiles between HIV-1 DNA GRT and RNA GRT.
Ying Zhou, Chuanfeng Zhang, Qi Sun, Tao Qiu, Qianjin Fan, Jing Lu, Haiyang Hu, Xiaoqin Xu, Dandan Yang, Haitao Yang   +9 more
doaj   +1 more source

Spatial distribution of HIV, HCV, and co-infections among drug users in the southwestern border areas of China (2004–2014): a cohort study of a national methadone maintenance treatment program

BMC Public Health, 2017
Background A methadone maintenance treatment (MMT) program to curb the dual epidemics of HIV/AIDS and drug use has been administered by China since 2004. Little is known regarding the geographic heterogeneity of HIV and hepatitis C virus (HCV) infections
Mingli Li, Rongjian Li, Zhiyong Shen, Chunying Li, Nengxiu Liang, Zhenren Peng, Wenbo Huang, Chongwei He, Feng Zhong, Xianyan Tang, Guanghua Lan   +10 more
doaj   +1 more source

HIV prevention in the south [PDF]

CDC allocates resources for HIV prevention interventions to populations most affected by HIV.cdc-hiv-prevention-south ...

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