Results 81 to 90 of about 636,107 (305)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The epidemiology of HIV among young people in sub-Saharan Africa: know your local epidemic and its implications for prevention.

, 2011
BACKGROUND: Broad patterns of HIV epidemiology are frequently used to design generic HIV programs in sub-Saharan Africa. METHODS: We reviewed the epidemiology of HIV among young people in sub-Saharan Africa, and explored the unique dynamics of infection ...
Changalucha, John, Doyle, Aoife M, Napierala Mavedzenge, Sue, Olson, Rick, Ross, David A   +4 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

"Condoms Are Reliable but I Am Not": A Qualitative Analysis of AIDS-Related Beliefs and Attitudes of Young Heterosexual Adults in Budapest, Hungary and St. Petersburg, Russia [PDF]

, 2006
HIV and STD prevention is an essential component of public health initiatives in countries throughout Central and Eastern Europe. Liberalization in sexual values, declining age at first sex, higher levels of sexual activity, and inconsistent condom use
, , , Bauer, Bukodi, Dehne, Dési, Engleman, Federal Service, HIV Infection, Hungarian Central, Lunin, Morris, Morse, Perlez, Pokrovsky, Pokrovsky VV, The, Tsybakova DA, UNAIDS   +19 more
core   +1 more source

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Spatial distribution of HIV, HCV, and co-infections among drug users in the southwestern border areas of China (2004–2014): a cohort study of a national methadone maintenance treatment program

BMC Public Health, 2017
Background A methadone maintenance treatment (MMT) program to curb the dual epidemics of HIV/AIDS and drug use has been administered by China since 2004. Little is known regarding the geographic heterogeneity of HIV and hepatitis C virus (HCV) infections
Mingli Li, Rongjian Li, Zhiyong Shen, Chunying Li, Nengxiu Liang, Zhenren Peng, Wenbo Huang, Chongwei He, Feng Zhong, Xianyan Tang, Guanghua Lan   +10 more
doaj   +1 more source

Concealment, communication and stigma: The perspectives of HIV-positive immigrant Black African men and their partners living in the United Kingdom [PDF]

, 2015
This study explored the perspectives of Black men, originally from East Africa, living in the United Kingdom and their families on what it means to live with diagnosed HIV.
Abigail Locke, Andrew Clifton, Bob Heyman, Glaser BG, John OA Owuor, Public Health England, Strauss AL, Van Wyk B   +7 more
core   +1 more source

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

A cross-sectional analysis of fingerstick blood self-microcollection for remote HIV suppression monitoring in Atlanta, Georgia, USA: a path to expanding access to continuum of care

AIDS Research and Therapy
Background Many people with HIV experience considerable barriers to accessing HIV clinic services. Options that would permit blood sampling that preclude the need for in-clinic visits and increase privacy would aid in overcoming many of the obstacles ...
Jeffrey A. Johnson, Amanda J. Smith, Ruth Dana, Erin Rogers, M. Leanne Ward, Ariana S. Tino, Vickie Sullivan, Wei Luo, Jin-fen Li, Patrick S. Sullivan   +9 more
doaj   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source