Results 71 to 80 of about 636,107 (305)

The HIV-associated tuberculosis epidemic--when will we act?

, 2010
Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus our attention on the regions with the greatest burden of disease, especially sub-Saharan Africa, and ...
Chimzizi, Rhehab, Corbett, Elizabeth L, De Cock, Kevin M, Harries, Anthony D, Harrington, Mark, Lawn, Stephen D, Maher, Dermot, Santos-Filho, Ezio T, Williams, Brian G, Zachariah, Rony   +9 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Bolstering State Efforts to Implement the National HIV/AIDS Strategy: Key Indicators and Recommendations for Policymakers and Community Stakeholders [PDF]

, 2015
The report builds upon the Centers for Disease Control and Prevention's (CDC) 2014 "State Prevention Progress Report," which provided state-level data on indicators related to national HIV prevention goals.

core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

New Approaches to HIV Prevention: Accelerating Research and Ensuring Future Access [PDF]

, 2006
Summarizes the state of research on new HIV prevention approaches and recommends ways to accelerate research and ensure rapid access to new prevention ...

core  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Thrombocytopenia according to antiretroviral drug combinations, viremia and CD4 lymphocytes among HIV-infected patients in Cameroon: a snapshot from the City of Yaoundé

BMC Research Notes, 2019
Objective Thrombocytopenia is an abnormal decrease in blood platelets, which can affect the prognosis of people living with HIV (PLHIV). In order to assess the burden of this haematological disorder, we evaluated the frequency of thrombocytopenia ...
Alex Durand Nka, Samuel Martin Sosso, Joseph Fokam, Yagai Bouba, Georges Teto, Rachel Simo Rachel, Aline Tiga, Junie Yimga, Elias Nchiwan Nukenine, Aubin Joseph Nanfack, Désiré Takou, Zélateur Aroga, Vittorio Colizzi, Alexis Ndjolo   +13 more
doaj   +1 more source

Addressing social issues in a universal HIV test and treat intervention trial (ANRS 12249 TasP) in South Africa: methods for appraisal [PDF]

, 2015
Background: The Universal HIV Test and Treat (UTT) strategy represents a challenge for science, but is also a challenge for individuals and societies.
AK Rowe, AVAC, B Grinsztejn, B Löwe, B Spire, Bruno Spire, C García-Moreno, C Iwuji, C Mugglin, CC Iwuji, Collins Iwuji, D Govindasamy, D Wilson, F Obare, F Tanser, F Yeji, France Lert, H Rooyen Van, J Bor, J Imrie, J Kim, J Theis, J Zaidi, JAC Hontelez, JH Oyugi, Joanna Orne-Gliemann, John Imrie, Joseph Larmarange, JW Eaton, K Chaiyachati, K Jean, K Kroenke, K Kroenke, K Sabapathy, M Duračinský, M Souville, MA Chesney, MW Hull, N Chimbindi, N McGrath, N McGrath, Nuala McGrath, P Carrieri, R Hayes, R Rabin, RL Spitzer, RM Granich, Rosemary Dray-Spira, S Boyer, S Cleary, S Gilbody, S Helleringer, Southern African HIV Clinicians Society, Sylvie Boyer, T Bärnighausen, T Bärnighausen, T Zuma, T Zuma, Tamsen Rochat, Thembelile Zuma, Till Bärnighausen, TJ Coates, V Bond, WL Holzemer, World Health Organisation, X Anglaret   +65 more
core   +7 more sources

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Investigation of HIV Incidence Rates in a High-Risk, High-Prevalence Kenyan Population

Journal of the International Association of Providers of AIDS Care, 2016
Cost-effective HIV prevention programs should target persons at high risk of HIV acquisition. We conducted an observational HIV incidence cohort study in Kisumu, Kenya, where HIV prevalence is triple that of the national rate.
Rennatus Mdodo DrPH, MS, Deborah Gust PhD, Fredrick O. Otieno DCMS, MPH, Eleanor McLellan-Lemal MA, Robert T. Chen MD, MA, Charles LeBaron MD, Felicia Hardnett MS, Kyle Turner MS, Richard Ndivo BSc, Clement Zeh PhD, Taraz Samandari MD, PhD, Lisa A. Mills MD   +11 more
doaj   +1 more source