Results 91 to 100 of about 95,049 (250)
Comprehending the Structure, Dynamics, and Mechanism of Action of Drug-Resistant HIV Protease. [PDF]
ACS Omega, 2023 Dakshinamoorthy A, Asmita A, Senapati S.
europepmc +1 more source
Microbiology and Immunology, EarlyView.ABSTRACT In this review, we introduce a promising strain for studying pathogenesis of nontuberculous mycobacterial pulmonary disease (NTM‐PD), Mycobacterium intracellulare M.i.198. M.i.198 was isolated from a patient with progressive Mycobacterium avium‐intracellulare complex pulmonary disease (MAC‐PD) in whom surgical operation was required to ...
Yoshitaka Tateishi +3 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche +11 more
wiley +1 more source
HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics. [PDF]
Protein J, 2023 Sheik Ismail Z +3 more
europepmc +1 more source
Brain Pathology, EarlyView.Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
Discovery of Novel HIV Protease Inhibitors Using Modern Computational Techniques. [PDF]
Int J Mol Sci, 2022 Okafor SN, Angsantikul P, Ahmed H.
europepmc +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease. [PDF]
Protein Sci, 2022 Samant N, Nachum G, Tsepal T, Bolon DNA.
europepmc +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background To report the 1‐year clinical outcomes of decellularised human corneal stromal lamina implantation, with or without autologous adipose‐derived adult stem cells (ADASCs), for advanced keratoconus in a European cohort. Methods In this prospective, randomised Phase I/IIa trial, 10 eyes of 10 patients were allocated to decellularised ...
Hao Zhang +7 more
wiley +1 more source
PLOS Global Public HealthCompared to HIV-1, HIV-2 infection is characterized by lower viral loads and slower decline in CD4 cells, however the majority of people living with HIV-2 (PLWH2) progress to AIDS and will benefit from antiretroviral therapy.
Dana N Raugi +12 more
doaj +1 more source