Results 101 to 110 of about 106,865 (295)

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Protease inhibitors to treat hepatitis C in the Swiss HIV Cohort Study: high efficacy but low treatment uptake

, 2015
OBJECTIVES Direct-acting antiviral agents (DAAs) have become the standard of care for the treatment of chronic hepatitis C virus (HCV) infection. We aimed to assess treatment uptake and efficacy in routine clinical settings among HIV/HCV coinfected ...
Ambrosioni, J, Decosterd, L, Furrer, H, Cavassini, M., Stoeckle, M, Schmid, P, Schaerer, V., Cavassini, M, Rauch, A., Decosterd, L., Ledergerber, B, Ledergerber, B., Kovari, H., Böni, J., Haubitz, S, Stoeckle, M., Haubitz, Sebastian, Rauch, A, Kovari, H, Aouri, M, Böni, J, Furrer, Hansjakob, Metzner, K.J., Schmid, P., Rauch, Andri, Furrer, H., Metzner, K J, Günthard, H.F., Ambrosioni, J., Schaerer, V, Günthard, H F, Aouri, M., Haubitz, S., Fehr, J, Fehr, J.   +34 more
core   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]

, 2010
Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael, Karl Salzwedel, Salzwedel Karl, Catherine S. Adamson, Eric O. Freed, Sakalian, M, Michael Sakalian, Adamson, Catherine S, Salzwedel, K, Freed Eric O, Freed, E.O., Adamson Catherine S   +11 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

The crosstalk between Dendritic and Natural Killer cells together with the function of Tumor Associated Macrophages (TAM) represent novel cancer-related targets for Human Immunodeficiency Type-1 Protease Inhibitors

, 2009
Inflammatory conditions and infections in selected organs increase the risk of cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis and subversion of ...
Ciaglia, Elena
core  

Poly-l-lactic acid for HIV-1 facial lipoatrophy: 48-week follow-up

, 2009
OBJECTIVES: Poly-l-lactic acid (PLA) injections modestly increase objectively assessed facial thickness but not facial soft tissue volume (FSTV) over 24 weeks. The durability of this response has not been well defined objectively.
Cooper, D.A., Petoumenos, K, Watson, J., Cooper, D., Carr, A, Baker, D., Carey, D, GD Rogers, Cooper, D. A., Petoumenos, K., Chuah, John, DA Cooper, Chuah, J, Carey, D., Rogers, GD, J Chuah, S Emery, Rogers, G.D., D Carey, K Petoumenos, D Baker, A Carr, Carr, A., Nolan, D., Baker, D, Emery, S, Rogers, Gary, Rogers, G. D., Watson, J, Emery, S., Cooper, DA, Chuah, J., J Watson   +32 more
core   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.

, 2013
Includes abstract.Includes bibliographical references.The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms.
Allie, Sameera
core