Results 91 to 100 of about 1,459,292 (318)

Synthesis and characterization of gold(I) thiolate derivatives and bimetallic complexes for HIV inhibition

Frontiers in Chemistry
Introduction: The human immunodeficiency virus (HIV) remains a significant global health concern, with a reported high infection rate of 38.4 million cases globally; an estimated 2 million new infections and approximately 700,000 HIV/AIDS-related deaths ...
Christian K. Adokoh, Akwasi Boadu, Akwasi Boadu, Isaac Asiamah, Clement Agoni   +4 more
doaj   +1 more source

Neuropathy among drug resistant HIV Patients treated in Jakarta

Journal of Infection in Developing Countries
Introduction: Some people living with HIV (PLWH) receiving ART in Indonesia display poor clearance of replicating virus. This has been associated with HIV-associated sensory neuropathy.
Ibnu A Ariyanto, Fitri Octaviana, Churi Wardah, Ekawati Beti, Silvia Widyaningtyas, Budiman Bela, Patricia Price, Amin Soebandrio   +7 more
doaj   +1 more source

A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads [PDF]

, 2006
Background. Our objective was to compare the rate of viral rebound and therapy failure in patients receiving abacavir or efavirenz as the third drug ( in addition to 2 non-abacavir nucleosides) in combination antiretroviral therapy ( cART) and to compare
Phillips, AN, L. Sighinolfi, D'ARMINIO MONFORTE A, R. Cauda, MOIOLI MC, Monforte, AD, COZZI-LEPRI A, DI GIAMBENEDETTO S, M. Mena, Sighinolfi, L, SIGHINOLFI L, A. Cozzi Lepri, Lichtner, M, ICoNA Study Group, Arlotti, M, M. Lichtner, Bongiovanni, M, Mena, M, M. Arlotti, UCSC Roma HIV Cohort Study Group, CAUDA R, A. N. Phillips, De Luca, A, Di Giambenedetto, S, Cozzi-Lepri, A, DE LUCA A, BONGIOVANNI M, PHILLIPS AN, UCSC-Roma HIV Cohort Study Grp, Narciso, P, Cauda, R, IMIT Study Grp, IMIT Study Group, A. De Luca, ICoNA Study Grp, MENA M, ARLOTTI M, NARCISO P, LICHTNER M, M. C. Moioli, Moioli, MC, S. Di Giambenedetto, P. Narciso, M. Bongiovanni, A. d’Arminio Monforte   +44 more
core   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Select HIV Protease Inhibitors Alter Bone and Fat Metabolismex Vivo *

Journal of Biological Chemistry, 2002
Human immunodeficiency virus (HIV) therapies have been associated with alterations in fat metabolism and bone mineral density. This study examined the effects of HIV protease inhibitors (PIs) on bone resorption, bone formation, and adipocyte ...
R. Jain, J. Lenhard
semanticscholar   +1 more source

Poly-l-lactic acid for HIV-1 facial lipoatrophy: 48-week follow-up [PDF]

, 2009
OBJECTIVES: Poly-l-lactic acid (PLA) injections modestly increase objectively assessed facial thickness but not facial soft tissue volume (FSTV) over 24 weeks. The durability of this response has not been well defined objectively.
Cooper, D.A., Petoumenos, K, Watson, J., Cooper, D., Carr, A, Baker, D., Carey, D, GD Rogers, Cooper, D. A., Petoumenos, K., Chuah, John, DA Cooper, Chuah, J, Carey, D., Rogers, GD, J Chuah, S Emery, Rogers, G.D., D Carey, K Petoumenos, D Baker, A Carr, Carr, A., Nolan, D., Baker, D, Emery, S, Rogers, Gary, Rogers, G. D., Watson, J, Emery, S., Cooper, DA, Chuah, J., J Watson   +32 more
core   +1 more source

Lenacapavir initiation with concomitant primidone: A case report with therapeutic drug monitoring

British Journal of Clinical Pharmacology, EarlyView.
Lenacapavir (LEN), a first‐in‐class capsid inhibitor, has unique pharmacokinetics that enable twice‐yearly dosing. LEN is not extensively metabolized, although it is a substrate of CYP3A4, which introduces drug–drug interactions concerns. As adoption and implementation of LEN for treatment and prevention increase, additional guidance on concomitant ...
Aaron S. Devanathan, Thomas Glowa, Emily M. Thompson, Amanda J. Saylor, Thomas D. Nolin, Sharon A. Riddler, Ken S. Ho   +6 more
wiley   +1 more source

Trends in Utilization of Statin Therapy and Contraindicated Statin Use in HIV‐‐Infected Adults Treated With Antiretroviral Therapy From 2007 Through 2015

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background HIV is associated with an increased risk for atherosclerotic cardiovascular disease, which may result in many people living with HIV taking a statin.
Robert S. Rosenson, Lisandro D. Colantonio, Greer A. Burkholder, Ligong Chen, Paul Muntner   +4 more
doaj   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Virtual Screening for HIV Protease Inhibitors: A Comparison of AutoDock 4 and Vina

PLoS ONE, 2010
Background The AutoDock family of software has been widely used in protein-ligand docking research. This study compares AutoDock 4 and AutoDock Vina in the context of virtual screening by using these programs to select compounds active against HIV ...
M. Chang, Christian Ayeni, S. Breuer, B. Torbett   +3 more
semanticscholar   +1 more source