Results 81 to 90 of about 1,459,292 (318)

HIV-1 Protease Inhibitors Based on Acyclic Carbohydrates

, 2016
A series of acyclic C2-symmetric HIV protease inhibitors readily accessible from d-mannitol have been developed.
Abderrahim Bouzide (2695402), Guido Zuccarello (3019770), Björn Classon (3012048), Bertil Samuelsson (1303401), Gunilla Niklasson (3042387), Helena Danielsson (3042390), Anders Hallberg (585061), Ingemar Kvarnström (2678440), Stefan C. T. Svensson (2652580), Magnus Brisander (3013629), Ulrika Nillroth (3019773), Anders Karlén (2497366)   +11 more
core   +1 more source

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study. [PDF]

, 2015
Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy.
Richard Gilson, McKendry, A, Gilson, R, Ana Milinkovic, Arenas-Pinto, A, Maini, M, Milinkovic, A, Anna McKendry, Peppa, D, Alejandro Arenas-Pinto, Dimitra Peppa, Mala Maini   +11 more
core   +2 more sources

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting

Journal of the International Association of Providers of AIDS Care, 2019
Introduction: The present study aimed to report the prevalent HIV-1 drug-resistant mutations in patients with HIV-1 alone and tuberculosis (TB) coinfection alone to improve our understanding of the mutation patterns and aid treatment decisions.
Nawaid Hussain Khan PhD, Mikashmi Kohli PhD, Kartik Gupta MD, Bimal Kumar Das MD, Ravindra Mohan Pandey PhD, Sanjeev Sinha MD   +5 more
doaj   +1 more source

Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

Virology Journal, 2012
Background Development of compensatory mutations within the HIV p7/p1 and p1/p6 protease cleavage site region has been observed in HIV-infected patients treated with protease inhibitors.
Sullivan James C, Zhang Eileen Z, Bartels Doug J, Tigges Ann, Dorrian Jennifer L, Kwong Ann D, Kieffer Tara L   +6 more
doaj   +1 more source

Molecular dynamics simulations of complex systems including HIV-1 protease [PDF]

, 2010
Advances in supercomputer architectures have resulted in a situation where many scienti fic codes are used on systems whose performance characteristics di ffer considerably from the platform they were developed and optimised for.
Kenway, O.A., Kenway, OA
core  

HIV protease inhibitors differentially inhibit adhesion of Candida albicans to acrylic surfaces

, 2010
Highly active antiretroviral therapy (HAART), using HIV protease inhibitors, is commonly used in the management of HIV infection. HIV protease inhibitors also have a direct effect on a key virulence factor of Candida albicans, its secreted aspartyl ...
Tsang, CSP, Hong, I
core   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Analysis of drug resistance in HIV protease

BMC Bioinformatics, 2018
Background Drug resistance in HIV is the major problem limiting effective antiviral therapy. Computational techniques for predicting drug resistance profiles from genomic data can accelerate the appropriate choice of therapy. These techniques can also be
Shrikant D. Pawar, Christopher Freas, Irene T. Weber, Robert W. Harrison   +3 more
doaj   +1 more source