Structure-based pharmacophore modeling, high-throughput screening, and molecular dynamics identify a novel DrugBank-derived HIV-1 protease inhibitor. [PDF]
Khazaal Nazal AS +3 more
europepmc +1 more source
ABSTRACT This study examined changes in anti‐Spike (anti‐S) antibodies (Abs) and type I interferon (IFN‐I) following the BNT162b2 vaccine in people living with HIV (PLWH) and analyzed the impact of demographic and immunological factors. In total, 75 PLWH and 28 healthy donors were followed at baseline (T0), at the second dose (T1), after the second ...
Federica Frasca +18 more
wiley +1 more source
Longitudinal Analysis of HIV-2 Proviral DNA Reveals Archived Protease Inhibitor Resistance and Reservoir Evolution over Eight Years. [PDF]
Gonçalves P +10 more
europepmc +1 more source
Sequence-specific alterations of epitope production by HIV protease inhibitors. [PDF]
Kourjian G +5 more
europepmc +1 more source
ABSTRACT Antibodies to Epstein‐Barr virus (EBV) proteins can predict nasopharyngeal carcinoma (NPC) risk. We previously defined a prototype EBNA1 protein panel and multiplex immunoblot assay that distinguishes NPC risk several years pre‐diagnosis.
Benjamin E. Warner +7 more
wiley +1 more source
Research progress on HIV-1 structural proteins and antiviral therapies. [PDF]
Wang H, Yuan J, Wang H.
europepmc +1 more source
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya +7 more
wiley +1 more source
Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers.
Goda JS +4 more
europepmc +1 more source
From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez +3 more
wiley +1 more source
Unveiling the Impact of Drug-Sensitive Mutations on HIV-1 Protease Dynamics: A Molecular Dynamics Simulation Study of the T12A, L63Q, and H69N Variants. [PDF]
Srihi H +5 more
europepmc +1 more source

