Results 191 to 200 of about 1,459,292 (318)

Applications of Click Chemistry in the Development of HIV Protease Inhibitors. [PDF]

Int J Med Chem, 2018
Mudgal MM, Birudukota N, Doke MA.
europepmc   +1 more source

Site‐specific O‐glycans influence lacritin structure and multimerization in tears

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, especially within its C‐terminal domain.
Vincent Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon Laurie, Stacy A. Malaker   +7 more
wiley   +1 more source

Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages. [PDF]

Viruses, 2018
Pasquereau S, Kumar A, Abbas W, Herbein G.   +3 more
europepmc   +1 more source

De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries. [PDF]

Chembiochem
Genetically encoded cyclic peptide libraries can be employed in cellular selection platforms to identify cyclic peptide inhibitors for therapeutic targets by directly selecting for desired biological activities. This review systematically summarizes representative studies and suggests future opportunities for using cellular selection for de novo cyclic
Yang L, Behera A, Meyers HJ, Wang T.
europepmc   +2 more sources

Cardiorenal Mortality and Safety Outcomes of GLP‐1 Receptor Agonists in Type 2 Diabetes With BMI Below 27 kg/m2: A Target Trial Emulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10498-10512, November 2026.
ABSTRACT Aims Cardiorenal evidence for glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) derives mainly from trials in overweight or obesity; data in adults with Type 2 diabetes (T2D) and body mass index (BMI) below 27 kg/m2 are limited. Materials and Methods We emulated a target trial in the TriNetX US Collaborative Network (index dates 2020 to ...
Shao‐Chia Chen, Yu‐Nan Huang, Pei‐Yun Li, Jo‐Ching Chen, Gideon Meyerowitz‐Katz, Shun‐Fa Yang, Pen‐Hua Su   +6 more
wiley   +1 more source

HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. [PDF]

Biochem Biophys Res Commun, 2019
Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH.   +9 more
europepmc   +1 more source

Identification of Prognostic Factors and Regulatory Pathways in Porto‐Sinusoidal Vascular Disorder

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare liver condition characterized by specific histological features primarily affecting the hepatic sinusoidal and periportal vasculature, in the absence of cirrhosis. This study aimed to identify prognostic factors and regulatory pathways associated with PSVD by integrating ...
Subin Heo, Do Kyung Yoon, Soyeon Shin, Dami Youn, Youngeun Yoo, In Hye Song, Hyo Jeong Kang, Young‐In Yoon, Kyunggon Kim, Seung Soo Lee, Sung Won Chung, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Mark Muthiah, Ho‐Su Lee, Won‐Mook Choi   +19 more
wiley   +1 more source

Medicinal Chemistry Aspects of Thiazole and Thiazolidine Derivatives as Fundamental Building Blocks to Design New NNRTIs Against HIV‐1 Reverse Transcriptase

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HIV‐1 reverse transcriptase (HIV‐1 RT) is a polymerase enzyme and a key target in HIV‐1 therapy. The discovery of selective HIV‐1 RT inhibitors has highlighted thiazole scaffolds and their derivatives, thiazolidine‐2‐one and thiazolidine‐2,4‐dione, as promising structures for the rational design of novel non‐nucleoside reverse transcriptase inhibitors (
José Arion da Silva Moura, Matheus Vinicius Guimarães de Melo, Diane Regis Santos do Nascimento, Thaynara Paula Warren Bezerra, Mathieu Métifiot, Patricia Recordon‐Pinson, Maira Galdino da Rocha Pitta, Marina Galdino da Rocha Pitta, Michelly Cristiny Pereira, Marie‐Line Andreola   +9 more
wiley   +1 more source

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

Proceedings of the National Academy of Sciences of the United States of America, 2007
Catherine Coffinier, Sarah E Hudon, Emily A. Farber, Sandy Chang, C. Hrycyna, S. Young, L. Fong   +6 more
semanticscholar   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, Volume 2, Issue 5, October 2026.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source