Results 201 to 210 of about 1,459,292 (318)

Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation

AIDS (London), 2003
M. Caron, M. Auclair, H. Sterlingot, M. Kornprobst, J. Capeau   +4 more
semanticscholar   +1 more source

Automated mRNA‐Based Detection of ER, PR, HER2, and Ki‐67 in Breast Cancer Tissue and Cytology Samples in Resource‐Limited Settings

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Accurate detection of estrogen and progesterone receptors (ER/PR), HER2, and Ki‐67 is essential for molecular classification of breast cancer and in deciding upon tailored treatment. In many low‐ and middle‐income countries (LMICs), access to histopathology and immunohistochemistry (IHC) is limited.
Partha Basu, Anuradha Talukdar, Poulome Mukherjee, Richard Muwonge, Eric Lucas, Monoj Kumar Deka, Amanjit Bal, Upasana Gautam, Manish Rohilla, Baneet Bansal, Veenu Singla, Siddhant Khare, Andre Lopes Carvalho, Anita Gadgil, Ravi Kannan, Radhika Srinivasan   +15 more
wiley   +1 more source

HIV Protease Inhibitor [PDF]

, 2020
openaire   +1 more source

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease. [PDF]

J Enzyme Inhib Med Chem, 2019
Maseko S, Padayachee E, Maphumulo S, Govender T, Sayed Y, Maguire G, Lin J, Naicker T, Baijnath S, Gerhardus KH.   +9 more
europepmc   +1 more source

The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults

AIDS (London), 2004
Mustafa A. Noor, R. Parker, E. O'Mara, D. Grasela, A. Currie, S. Hodder, F. Fiedorek, D. Haas   +7 more
semanticscholar   +1 more source

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages.

Journal of Clinical Investigation, 2003
James L. Dressman, Jeanie F. Kincer, Sergey V. Matveev, Ling Guo, R. Greenberg, T. Guerin, David G. Meade, Xiang-An Li, Weifei Zhu, Annette M. Uittenbogaard, Melinda E. Wilson, E. Smart   +11 more
semanticscholar   +1 more source

Phytochemistry, Pharmacological Potential, and Future Prospects of Abietane‐Type Diterpenoids From Salvia rosmarinus

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The review delves into the findings on abietane diterpenes from Salvia rosmarinus. It comprises the phytochemistry, biological activities, biosynthesis, degradation studies, semisynthesis, and pharmacokinetic studies of these compounds. The potential of these compounds for future development has also been highlighted.
Rida Siddiqui, Vipin Singh, Kapil Dev
wiley   +1 more source

ER Stress Regulates HIV Tat and Alcohol‐Induced NLRP6 Activation in Astrocytes

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
HIV Tat and ethanol synergistically induce ER stress in astrocytes, activating an ER stress‐NLRP6 inflammasome axis that drives caspase‐1 activation and IL‐1β/IL‐18 release. Targeting ER stress or NLRP6 effectively suppresses astrocytic neuroinflammation, identifying a novel therapeutic pathway for alcohol‐exacerbated NeuroHIV.
Seema Singh, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy   +3 more
wiley   +1 more source