Results 21 to 30 of about 1,459,292 (318)

HIV protease inhibitors and obesity [PDF]

Current Opinion in Endocrinology, Diabetes and Obesity, 2010
To review the current scientific literature and recent clinical trials on HIV protease inhibitors and their potential role in the pathogenesis of lipodystrophy and metabolic disorders.HIV protease inhibitor treatment may affect the normal stimulatory effect of insulin on glucose and fat storage.
Erdembileg, Anuurad, Andrew, Bremer, Lars, Berglund   +2 more
openaire   +2 more sources

The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage? [PDF]

, 2011
Background: Although being considered as a rarely observed HIV-1 protease mutation in clinical isolates, the L76V-prevalence increased 1998-2008 in some European countries most likely due to the approval of Lopinavir, Amprenavir and Darunavir which can ...
Braun, Patrick, Ehret Robert, Naeth, Gudrun, Frank Wiesmann, Tappe André, Tappe, André, Rolf Kaiser, Martin Stürmer, Hauke Walter, Jan Vachta, Walter, Hauke, André Tappe, Ehret, Robert, Stürmer Martin, Thomas Berg, Kaiser Rolf, Robert Ehret, Berg Thomas, Naeth Gudrun, Knechten Heribert, Gudrun Naeth, Patrick Braun, Knechten, Heribert, Stürmer, Martin, Wiesmann, Frank, Vachta, Jan, Heribert Knechten, Kaiser, Rolf, Berg, Thomas, Walter Hauke, Martin Däumer, Braun Patrick, Däumer Martin, Wiesmann Frank, Vachta Jan, Däumer, Martin   +35 more
core   +1 more source

Proteochemometric modeling of HIV protease susceptibility

BMC Bioinformatics, 2008
Background A major obstacle in treatment of HIV is the ability of the virus to mutate rapidly into drug-resistant variants. A method for predicting the susceptibility of mutated HIV strains to antiviral agents would provide substantial clinical benefit ...
Prusis Peteris, Spjuth Ola, Eklund Martin, Lapins Maris, Wikberg Jarl ES   +4 more
doaj   +1 more source

HIV protease inhibitors disrupt astrocytic glutamate transporter function and neurobehavioral performance

AIDS (London), 2016
Objective:The neurotoxic actions of the HIV protease inhibitors, amprenavir (APV) and lopinavir (LPV) were investigated. Design:With combination antiretroviral therapy (cART), HIV-infected persons exhibit neurocognitive impairments, raising the ...
P. Vivithanaporn, Eugene Asahchop, S. Acharjee, G. Baker, C. Power   +4 more
semanticscholar   +1 more source

The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study

BMC Cancer, 2021
Background The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase ...
Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin, Elizabeth Chiao   +10 more
doaj   +1 more source

Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection [PDF]

, 2004
The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration less than or equal to0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir ...
Joseph B. Margolick, Routy, JP, Susan J. Little, Frost, SDW, Leigh Brown, AJ, Connick, E, Little, SJ, Markowitz, M, Elizabeth Connick, Douglas D. Richman, Collier, AC, Richman, DD, Hellmann, NS, Brian Conway, Daar, ES, Good, B, Jacques Corbeil, Eric S. Daar, Margolick, JB, Simon D. W. Frost, Corbeil, J, Jean-Pierre Routy, Nicholas S. Hellmann, Benjamin Good, Viviana Simon, Simon, V, Ann C. Collier, Martin Markowitz, Conway, B, Andrew J. Leigh Brown   +29 more
core   +1 more source

Comparing the Performance of Molecular Docking Tools for HIV-1 Protease Inhibitors

Journal of Advanced Engineering and Computation, 2023
Human immunodeficiency virus (HIV) continues to pose a significant public health threat worldwide, disproportionately affecting marginalized and vulnerable populations despite advancements in prevention and treatment.
Han Thi Ngoc Pham, Huong Thi Thu Phung
doaj   +1 more source

Early structural and functional changes of the vasculature in HIV-infected children: Impact of disease and antiretroviral therapy [PDF]

, 2005
Background - Premature cardiovascular disease is increasingly recognized in HIV-infected patients, but the mechanisms involved are unclear. The purpose of this study was to determine the impact of HIV infection and antiretroviral therapy (ART) on markers
Clapson, Margaret, Halcox, Julian P., Donald, Ann E., Green, H, Halcox, JP, Deanfield, John E., Muriel Caslake, Charakida, M, Klein, Nigel J., Clapson, M, Caslake, M, Gibb, Diana M., Dunn, DT, Storry, C, Margaret Clapson, David T. Dunn, Clare Storry, Donald, AE, In Hiv-infected Children, Storry, Clare, Hannah Green, Green, Hannah, Diana M. Gibb, Nigel J. Klein, Gibb, DM, Klein, NJ, Deanfield, JE, Charakida, Marietta, Julian P. Halcox, Marietta Charakida, Caslake, Muriel, Ann E. Donald, Dunn, David T., John E. Deanfield   +33 more
core   +1 more source

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

Biology, 2012
Designing HIV-1 protease inhibitors that overcome drug-resistance is still a challenging task. In this study, four clinical isolates of multi-drug resistant HIV-1 proteases that exhibit resistance to all the US FDA-approved HIV-1 protease inhibitors and ...
Ladislau C. Kovari, Iulia A. Kovari, Joseph S. Brunzelle, Samuel J. Reiter, Zhigang Liu, Tamaria G. Dewdney, Yong Wang   +6 more
doaj   +1 more source