Results 271 to 280 of about 207,470 (285)

Intracellular Metabolism of Nucleoside/Nucleotide Analogues: a Bottleneck to Reach Active Drugs on HIV Reverse Transcriptase.

Current drug metabolism, 2016
BACKGROUND To date, the most effective way to treat HIV is to use a highly active antiretroviral therapy (HAART) that combines three or more different drugs.
A. Varga, C. Lionne, B. Roy
semanticscholar   +1 more source

An integrated molecular dynamics, principal component analysis and residue interaction network approach reveals the impact of M184V mutation on HIV reverse transcriptase resistance to lamivudine.

Molecular Biosystems, 2014
The emergence of different drug resistant strains of HIV-1 reverse transcriptase (HIV RT) remains of prime interest in relation to viral pathogenesis as well as drug development. Amongst those mutations, M184V was found to cause a complete loss of ligand
S. Bhakat, Alberto J. M. Martin, M. Soliman   +2 more
semanticscholar   +1 more source

Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.

Future Microbiology, 2011
In this article, we summarize recent knowledge on drug-resistance mutations within HIV reverse transcriptase (RT). Several large-scale HIV-1 genotypic analyses have revealed that the most prevalent nucleos(t)ide analog RT inhibitor (NRTI)-resistance ...
S. Ibe, W. Sugiura
semanticscholar   +1 more source

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.

Science, 1992
A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of AIDS, reveals an asymmetric dimer.
Jimin Wang, LA Kohlstaedt, J. Friedman, M. Franklin, J. Wang, James A. Hartling, Akma Sattar, WH Konigsberg, M. Stahley, AB Kosek, T. Steitz, LF Silvian, SJ Smerdon   +12 more
semanticscholar   +1 more source

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

Science, 1998
A combinatorial disulfide cross-linking strategy was used to prepare a stalled complex of human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal structure of
H. Huang, R. Chopra, G. Verdine, S. Harrison   +3 more
semanticscholar   +1 more source

Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid.

Journal of Natural Products, 1989
Four new tetragalloylquinic acids, 3,5-di-O-galloyl-4-O-digalloylquinic acid, 3,4-di-O-galloyl-5-O-digalloylquinic acid, 3-O-digalloyl-4,5-di-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid, were isolated and characterized from a commercial ...
M. Nishizawa, T. Yamagishi, G. Dutschman, W. Parker, A. Bodner, R. Kilkuskie, Y. Cheng, K. Lee   +7 more
semanticscholar   +1 more source

Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.

Journal of Natural Products, 1990
Nine tannins, including gallo- and ellagitannins, were evaluated as potential inhibitors of HIV replication. 1,3,4-Tri-O-galloylquinic acid [1], 3,5-di-O-galloyl-shikimic acid [2], 3,4,5-tri-O-galloylshikimic acid [3], punicalin [6], and punicalagin [7 ...
Gen Ichiro Nonaka, I. Nishioka, Makoto Nishizawa, Takashi Yamagishi, Yoshiki Kashiwada, G. Dutschman, Anne J. Bodner, R. Kilkuskie, Yung-Chi Cheng, K. Lee   +9 more
semanticscholar   +1 more source

Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana.

Journal of Natural Products, 1994
The first flavone-xanthone C-glucoside, swertifrancheside, was isolated from Swertia franchetiana, and its structure was elucidated on the basis of spectroscopic analysis as 1,5,8-trihydroxy-3-methoxy-7-(5',7',3'',4''- tetrahydroxy-6'-C-beta-D ...
J. Wang, C. Hou, Y. L. Liu, L. Lin, R. Gil, G. Cordell   +5 more
semanticscholar   +1 more source

Characterization and clinical association of antibody inhibitory to HIV reverse transcriptase activity.

Science, 1987
Reverse transcriptase activity of the human immunodeficiency virus (HIV) was blocked in vitro by immunoglobulin G (IgG) derived from certain individuals infected with this retrovirus.
J. Laurence, A. Saunders, J. Kulkosky
semanticscholar   +1 more source

HIV reverse transcriptase structure-function relationships.

Biochemistry, 1991
HIV reverse transcriptase (RT) is the target of the most widely used treatments for AIDS. Biochemical and mutagenesis studies performed on HIV-1 RT are reviewed in light of the enzyme's structure and functions.
A. Jacobo-Molina, Edward A Arnold
semanticscholar   +1 more source