Results 101 to 110 of about 246,153 (308)

Impact of Schistosoma mansoni Infection on the Gut Microbiome and Hepatitis B Vaccine Immune Response in Fishing Communities of Lake Victoria, Uganda

Vaccines
Objective: Schistosoma mansoni (S. mansoni) infection is endemic in Ugandan fishing communities. We investigated its potential impact on Hepatitis B (Hep B) vaccine responses and its role in mediating the association between the gut microbiome and long ...
Yan Wang, Ariana K. Waters, Geofrey Basalirwa, Ali Ssetaala, Juliet Mpendo, Annemarie Namuniina, Emily Keneema, David Kiiza, Jacqueline Kyosiimire-Lugemwa, Yunia Mayanja, Brenda Okech, Sylvia Kiwuwa-Muyingo   +11 more
doaj   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice

Frontiers in Immunology, 2019
BCG is currently the only licensed vaccine against tuberculosis (TB) and confers protection against meningitis and miliary tuberculosis in infants, although pulmonary disease protection in adults is inconsistent. Recently, promising HIV-1 immunogens were
Athina Kilpeläinen, Narcís Saubi, Núria Guitart, Nathifa Moyo, Edmund G. Wee, Krupa Ravi, Tomáš Hanke, Tomáš Hanke, Joan Joseph   +8 more
doaj   +1 more source

Bridging the Gaps between Fundamental, Preclinical and Clinical Research: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise (the Enterprise) convened a two-day workshop on 17-18 September 2009, at the Enterprise offices in New York; to discuss approaches to bridging the gaps between fundamental,preclinical and clinical HIV vaccine research ...
Brigitte Autran, Lawrence Corey, Louis Picker, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +3 more sources

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

A Qualitative Study of Perceived Risk for HIV Transmission among Police Officers in Dar es Salaam, Tanzania. [PDF]

, 2013
Understanding people's views about HIV transmission by investigating a specific population may help to design effective HIV prevention strategies. In addition, knowing the inherent sexual practices of such a population, as well as the risky circumstances
Asli Kulane, BM Nyombi, CO Airhihenbuwa, D Morgan, E Tarimo, EA Tarimo, Edith AM Tarimo, EJ Essien, EJ Mmbaga, EJ Mmbaga, EO Akinnawo, H Yang, International AIDS Vaccine Initiative, KI Yahya-Malima, L Dahlgren, M Bakari, M Bakari, Muhammad Bakari, N Mankayi, PC Whitehead, S Rerks-Ngarm, S Thorne, S Thorne, SC Kane, SH Miles, TACAIDS, Tanzania Commission for AIDS (TACAIDS), Thecla W Kohi, UA Nwokoji, UNAIDS, UNAIDS   +30 more
core   +1 more source

Preclinical development of BCG.HIVA2auxo.int, harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity

Human Vaccines & Immunotherapeutics, 2017
One of the critical issues that should be addressed in the development of a BCG-based HIV vaccine is genetic plasmid stability. Therefore, to address this issue we have considered using integrative vectors and the auxotrophic mutant of BCG complemented ...
Aakash Mahant, Narcís Saubi, Yoshiki Eto, Núria Guitart, Josep Ma Gatell, Tomáš Hanke, Joan Joseph   +6 more
doaj   +1 more source

Preclinical Assessment of HIV Vaccines and Microbicides by Repeated Low-Dose Virus Challenges [PDF]

, 2005
BACKGROUND: Trials in macaque models play an essential role in the evaluation of biomedical interventions that aim to prevent HIV infection, such as vaccines, microbicides, and systemic chemoprophylaxis.
Feinberg, Mark B, Longini, Ira M, Regoes, Roland R, Staprans, Silvija I   +3 more
core   +5 more sources

Assessing Vaccine Confidence Using the Vaccine Hesitancy Scale Among Adolescent Girls and Young Women at Risk of HIV Acquisition Living in Uganda, Zambia, and South Africa

Vaccines
Background: Vaccine hesitancy (VH) remains a major threat to global health that can reverse the progress in tackling vaccine-preventable diseases. Vaccine uptake among adolescent Girls and young women (AGYW) is often low. We assessed VH using a validated
Nasimu Kyakuwa, Ali Ssetaala, Matt A. Price, Annet Nanvubya, Joel M. Abyesiza, Geofrey Basalirwa, Brenda Okech, Juliet Mpendo, Mubiana Inambao, Kawela Mumba-Mwangelwa, Chishiba Kabengele, Suzanna C. Francis, Pholo Maenetje, Ken Ondeng’e, Vinodh Edward, William Kilembe, Monica O. Kuteesa   +16 more
doaj   +1 more source

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

EBioMedicine, 2015
Human monoclonal antibody CH58 isolated from an RV144 vaccinee binds at Lys169 of the HIV-1 Env gp120 V2 region, a site of vaccine-induced immune pressure.
Nathan I. Nicely, Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S. Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Jaranit Kaewkungwal, Merlin L. Robb, Robert J. O'Connell, Nelson L. Michael, Jerome H. Kim, Hua-Xin Liao, S. Munir Alam, Kwan-Ki Hwang, Mattia Bonsignori, Barton F. Haynes   +17 more
doaj   +1 more source