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Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial. [PDF]
EBioMedicineMiner MD +22 more
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Comprehension of informed consent and voluntary participation in registration cohorts for phase IIb HIV vaccine trial in Dar Es Salaam, Tanzania: a qualitative descriptive study. [PDF]
BMC Med EthicsIseselo MK, Tarimo EAM.
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Oral Preexposure Prophylaxis Uptake and Discontinuation in the HIV Vaccine Trials Network 704/HIV Prevention Trials Network 085 Study: Implications for Biomedical Human Immunodeficiency Virus Prevention Trials. [PDF]
Open Forum Infect DisCantos VD +15 more
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Trends in Microbiology, 1995
Relatively recently, mathematical models have been applied to issues r elated to HIV vaccination. Significant progress has been made towards understanding how rather ineffective vaccines will perform in trials and in the community, but some areas still need research.
Mclean, Angela R., Blower, Sally M.
openaire +3 more sources
Relatively recently, mathematical models have been applied to issues r elated to HIV vaccination. Significant progress has been made towards understanding how rather ineffective vaccines will perform in trials and in the community, but some areas still need research.
Mclean, Angela R., Blower, Sally M.
openaire +3 more sources
Current Topics in Medicinal Chemistry, 2003
Antiretroviral therapy with potent combinations of drugs has been responsible for a significant decline in the occurrences of AIDS defining conditions and death in the developed world. However, therapy requires life-long use and is complicated by relatively high failure rates, significant toxicities, adherence difficulties and the development of ...
Bruce L, Gilliam, Robert R, Redfield
openaire +2 more sources
Antiretroviral therapy with potent combinations of drugs has been responsible for a significant decline in the occurrences of AIDS defining conditions and death in the developed world. However, therapy requires life-long use and is complicated by relatively high failure rates, significant toxicities, adherence difficulties and the development of ...
Bruce L, Gilliam, Robert R, Redfield
openaire +2 more sources
Drugs of Today, 2004
Amino acid sequences of the HIV-1 surface protein gp120 show extensive variations. Some of the peptide or DNA vaccines using the V3-loop of gp120 can trigger antibody production against some isolates of HIV, but these antibodies are not protective against other isolates.
Tai Te, Wu, George, Johnson
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Amino acid sequences of the HIV-1 surface protein gp120 show extensive variations. Some of the peptide or DNA vaccines using the V3-loop of gp120 can trigger antibody production against some isolates of HIV, but these antibodies are not protective against other isolates.
Tai Te, Wu, George, Johnson
openaire +2 more sources
International Journal of Immunopharmacology, 1991
The immunoregulatory mechanisms responsible for effective the in vivo post-infection control of HIV are unknown. In the setting of natural HIV infection, host-directed immune responses directed against gp120 are minimal. This includes poor gp120 epitope specific antibody responses to C1, C2 and C3; lack of T-cell recognition and proliferation to gp120;
D L, Birx, R R, Redfield
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The immunoregulatory mechanisms responsible for effective the in vivo post-infection control of HIV are unknown. In the setting of natural HIV infection, host-directed immune responses directed against gp120 are minimal. This includes poor gp120 epitope specific antibody responses to C1, C2 and C3; lack of T-cell recognition and proliferation to gp120;
D L, Birx, R R, Redfield
openaire +2 more sources
Frontiers in Bioscience, 2005
For the past two decades, scientists have aggressively pursued the development of a vaccine against human immunodeficiency virus (HIV). The magnitude of this effort is unprecedented in the history of infectious diseases. However, difficulties in finding promising candidate vaccines have limited the number of clinical efficacy trials.
Mahender, Singh +2 more
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For the past two decades, scientists have aggressively pursued the development of a vaccine against human immunodeficiency virus (HIV). The magnitude of this effort is unprecedented in the history of infectious diseases. However, difficulties in finding promising candidate vaccines have limited the number of clinical efficacy trials.
Mahender, Singh +2 more
openaire +2 more sources
Infectious Disease Clinics of North America, 1999
In summary, the development of HIV vaccines has progressed from simple first-generation env subunit vaccines to second-generation vaccines containing multiple subunits. Vaccines with epitopes for CMI and Ab responses have broadened the immune response and the potential efficacy of these vaccines.
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In summary, the development of HIV vaccines has progressed from simple first-generation env subunit vaccines to second-generation vaccines containing multiple subunits. Vaccines with epitopes for CMI and Ab responses have broadened the immune response and the potential efficacy of these vaccines.
openaire +2 more sources