Results 91 to 100 of about 223,968 (292)

HLA-B27 modulates intracellular growth of Salmonella pathogenicity island 2 mutants and production of cytokines in infected monocytic U937 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Salmonella enterica serovar Enteritidis PT4 KS8822/88 replicates rapidly in HLA-B27-transfected human monocytic U937 cells. In this process, Salmonella pathogenicity island 2 (SPI-2) genes play a crucial role.
Shichao Ge, Qiushui He, Kaisa Granfors
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C., Kuon, W., Pohla, Heike, Tabaczewski, P., Weiss, Elisabeth H.   +4 more
core   +1 more source

Clinical Features of Acute Anterior Uveitis with Complicated Course in a Slovenian Patient Population

Journal of Ophthalmology, 2020
Purpose. To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27− AAU in the population of Slovenian patients.
Katarina Vergot, Sasa Pockar, Lan Umek, Natasa Vidovic Valentincic   +3 more
doaj   +1 more source

Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia : Results From a UK National Register [PDF]

, 2017
The British Society for Rheumatology (BSR) Biologics Register in Ankylosing Spondylitis is funded by the BSR and they have receive funds for this from Pfizer, AbbVie and UCB.
Atzeni, Fabiola, Barnish, Maxwell S, Haywood, Kirstie L, Jones, Gareth T, MacFarlane, Gary J, Martin, Kathryn R, Packham, Jonathan, Pathan, Ejaz, Siebert, Stefan   +8 more
core   +2 more sources

The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion *

Molecular & Cellular Proteomics, 2017
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding
Eilon Barnea, Dganit Melamed Kadosh, Y. Haimovich, N. Satumtira, M. Dorris, Mylinh T. Nguyen, R. Hammer, T. Tran, R. Colbert, J. Taurog, A. Admon   +10 more
semanticscholar   +1 more source

Original paper Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis

Rheumatology, 2015
Introduction: Human leukocyte antigen B27 (HLA-B27) is considered as a risk factor for development of juvenile idiopathic arthritis (JIA). The aim of this study was to analyse the prevalence of HLA-B27 antigen in JIA categories and its influence on ...
Zbigniew Żuber, Dorota Turowska-Heydel, Małgorzata Sobczyk, Jerzy Chudek   +3 more
doaj   +1 more source

Evaluating Associations Between Ankylosing Spondylitis, Torque Teno Virus and Polymorphisms in Interleukin 6 and Vitamin D Receptor Genes

International Journal of Immunogenetics, EarlyView.
ABSTRACT The etiology of ankylosing spondylitis (AS) is complex and not yet fully understood. Interleukin‐6 (IL‐6), vitamin D and the vitamin D receptor (VDR) play an important role in modulating immune response, and Torque teno virus is considered a marker of immune status. This case–control study aimed to investigate the predisposition to AS. A total
Dănuț Cimponeriu, Lavinia‐Mariana Berca, Irina Radu, Mihai Toma, Remus Nica, Silvia Nica, Roxana Măciucă   +6 more
wiley   +1 more source

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.

PLoS ONE, 2015
ObjectivesHLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis.
Osiris Marroquin Belaunzaran, Sascha Kleber, Stefan Schauer, Martin Hausmann, Flora Nicholls, Maries Van den Broek, Sravan Payeli, Adrian Ciurea, Simon Milling, Frank Stenner, Jackie Shaw, Simon Kollnberger, Paul Bowness, Ulf Petrausch, Christoph Renner   +14 more
doaj   +1 more source

Serum antibodies in first-degree relatives of patients with IBD: A marker of disease susceptibility? A follow-up pilot-study after 7 years [PDF]

, 2005
Introduction: Various disease-specific serum antibodies were described in patients with inflammatory bowel disease and their yet healthy first-degree relatives.
H.P. Török, J. Glas, H.C. Hollay, R. Gruber, M. Osthoff, L. Tonenchi, C. Brückl, T. Mussack, M. Folwaczny, C. Folwaczny, Glas J, Quinton JF, Ruemmele FM, Cambridge G, Colombel JF, Shanahan F, Hoffman IE, Torok HP, Seibold F, Folwaczny C, Folwaczny C, Folwaczny C, Seibold F, Shanahan F, Folwaczny C, Bansi DS, Klebl FH, Klebl FH, Torok HP, Lombardi G   +29 more
core   +4 more sources

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population

Mediators of Inflammation, 2018
Background and Objectives Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-
M. A. Rocha Loures, Luciana C Macedo, D. M. Reis, C. F. Oliveira, Jean L Meneguetti, Gabriela F Martines, J. S. F. Neves, Eliana de Souza, A. Sell, J. Visentainer   +9 more
semanticscholar   +1 more source