Results 81 to 90 of about 28,642 (221)

Analysis of Somatic Mutations and Immunotherapy Biomarkers in Chinese Patients With Non‐Small Cell Lung Cancer During 2019–2024: A Retrospective Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Understanding genetic alterations in lung cancer remains challenging due to tumor heterogeneity and malignancy. This study aimed to investigate somatic variations and immune‐related biomarkers in Chinese patients with NSCLC.
Xiumei Liu, Weigong Chen, Chengqi Xin, Zexu Wang, Kaiyu Yi, Liang Wang, Jing Liu   +6 more
wiley   +1 more source

HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats.

PLoS ONE, 2015
ObjectivesHLA-B27 is a common genetic risk factor for the development of Spondyloarthritides (SpA). HLA-B27 can misfold to form cell-surface heavy chain homodimers (B272) and induce pro-inflammatory responses that may lead to SpA pathogenesis.
Osiris Marroquin Belaunzaran, Sascha Kleber, Stefan Schauer, Martin Hausmann, Flora Nicholls, Maries Van den Broek, Sravan Payeli, Adrian Ciurea, Simon Milling, Frank Stenner, Jackie Shaw, Simon Kollnberger, Paul Bowness, Ulf Petrausch, Christoph Renner   +14 more
doaj   +1 more source

A Review of Ankylosing Spondylitis [PDF]

, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C., Kuon, W., Pohla, Heike, Tabaczewski, P., Weiss, Elisabeth H.   +4 more
core   +1 more source

Effectiveness and Safety of Baricitinib for Juvenile Idiopathic Arthritis–Associated Uveitis or Chronic Anterior Antinuclear Antibody–Positive Uveitis

Arthritis Care &Research, Volume 78, Issue 4, Page 431-438, April 2026.
Objective To evaluate the efficacy and safety of baricitinib in pediatric patients with active juvenile idiopathic arthritis–associated uveitis (JIA‐U) or chronic anterior antinuclear antibody–positive uveitis, who had an inadequate response to methotrexate (MTX) or biologic disease‐modifying antirheumatic drugs (bDMARDs).
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Y. Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Clinical phenotype, MRI inflammatory involvement, and treatment patterns in HLA-B27 positive and negative axial spondyloarthritis: a Saudi MRI-based cohort study

BMC Rheumatology
Background HLA-B27 is strongly associated with axial spondyloarthritis (axSpA) and influences disease phenotype, though its prevalence and clinical relevance vary by population. Magnetic resonance imaging (MRI)-based cohorts offer substantial information
Abdallah Alqethami, Mohammed Basalama, Samiyah Alsaedi, Khulud Alqahtani, Eman Alsindi, Sabri Alsaeedi, Roaa Mahroos, Maysoon Taher   +7 more
doaj   +1 more source

Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues [PDF]

, 2016
Copyright © 2015 by the American College of Rheumatology. Objective To characterize the alterations, as well as their mechanisms, induced in the HLA-B27-bound peptidome expressed in live cells by the natural ERAP1 polymorphisms predisposing to ankylosing
Akram, Alvarez-Navarro, Andres, Brown, Burton, Calvo, Chang, Chen, Constantino, Cortes, Ellis, Evans, Evnouchidou, Evnouchidou, Garcia-Medel, Garcia-Medel, Garcia-Medel, Goto, Haroon, Harvey, Hearn, James, Kirino, Kochan, Manz, Marcilla, Martin-Esteban, Nguyen, Paradela, Paradela, Reeves, Saric, Seregin, Serwold, Strange, Zemmour   +35 more
core   +1 more source

A Probable Case of Postpartum Sacroiliac Joint Tuberculosis: The Diagnostic Value of Imaging in a High‐Endemic Setting

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Tuberculous sacroiliitis is a rare form of osteoarticular tuberculosis and is particularly uncommon in the postpartum period. Its presentation is often nonspecific and can mimic more common postpartum musculoskeletal or infectious conditions, leading to delayed diagnosis, especially in high tuberculosis‐endemic regions. We report the case of a
H. Saad Nasir, Huda Raja, Abdullah Nadeem, Shuja Shaukat, Shabih Ayesha, Nahid Khalid Raufi   +5 more
wiley   +1 more source

Therapeutic Remodeling of the Gut Microbiome as a Strategy to Restore Immune Tolerance in Autoimmunity

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This graphical abstract illustrates how altered gut microbiota lead to autoimmunity. It shows that gut dysbiosis causes a “leaky gut” and activates autoreactive intestinal immune cells, which then migrate to other organs, ultimately triggering systemic autoimmune responses.
Behshad Boroumand, Amirhossein Jaberi, Ghazal Zamani, Ehsan Zandi, Farshad Zare, Milad Vahedinezhad, Elham Abdollahi, Sepideh KarkonShayan, Sasan GhazanfarAhari, Mustafa Sattar   +9 more
wiley   +1 more source

HLA-B27 Frequency and Clinical Correlates in Turkish Patients with Various Subtypes of Spondyloarthritis: A Single-Center Cohort Study

Namık Kemal Tıp Dergisi
Aim: This study aimed to evaluate the frequency of human leukocyte antigen (HLA)-B27 positivity and its clinical correlations in Turkish patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated ...
Dilara BULUT GÖKTEN, Hilmi TOZKIR, Ömer Atakan SOĞUR, Rıdvan MERCAN   +3 more
doaj   +1 more source