Results 111 to 120 of about 223,968 (292)

Digital Behavioral Therapy Improves Outcome in Patients With Axial Spondyloarthritis and Persistent Pain: A Randomized Controlled Trial

Arthritis Care &Research, Volume 78, Issue 1, Page 85-95, January 2026.
Objective Axial spondyloarthritis (axSpA) is often associated with persistent pain despite effective anti‐inflammatory treatment. Digital health applications (DHAs) provide innovative approaches to address multidimensional aspects of persistent pain through psychological and behavioral strategies. The aim of this study was to assess the impact of a DHA
David Kiefer, Yade Sonkaya, Dietmar Krause, Markus Voglau, Bernhard Mintrop, Imke Redeker, Xenofon Baraliakos, Uta Kiltz   +7 more
wiley   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]

, 2018
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F., Ferrante A., Guggino G., Rizzo A.   +3 more
core   +1 more source

HLA-B27: what's new? [PDF]

Rheumatology, 2010
The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the aetiopathogenesis of SpA and other diseases, and its protective action in certain infections, continue to challenge our understanding of its immunobiology and physiological roles. Animal studies have helped to cast light on ways in which HLA-B27 exerts its effects.
openaire   +2 more sources

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

Arthritis &Rheumatology, Volume 78, Issue 1, Page 152-165, January 2026.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J. A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Avaliação clínica, laboratorial e radiográfica de brasileiros com espondiloartropatias Clinical, laboratorial and radiographic evaluation in Brazilians with spondyloarthropaties

Revista Brasileira de Reumatologia, 2006
OBJETIVO: analisar o padrão de doença de pacientes brasileiros com espondiloartropatias (EAP). PACIENTES E MÉTODOS: foram avaliados 156 pacientes por meio de análise descritiva e análise de associação uni e multivariada entre a distribuição das ...
Carlos Alexandre de Souza Bomtempo, Ricardo da Cruz Lage, Gilda Aparecida Ferreira, Marco Antonio Parreiras de Carvalho   +3 more
doaj   +1 more source

Estudio de las manifestaciones extraarticulares en pacientes con espondiloartritis en el área de salud de La Plana [PDF]

, 2017
Treball Final de Grau en Grau en Medicina. Codi: MD1158. Curs: 2016/2017Objetivos: La uveítis, psoriasis y enfermedad inflamatoria intestinal son las manifestaciones extraarticulares que más frecuentemente se asocian a las Espondiloartropatías (EsA ...
Lis Sancerni, María Dolores
core  

Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. [PDF]

, 2014
OBJECTIVES: Interleukin (IL)-23 has been implicated in the pathogenesis of ankylosing spondylitis (AS). The aim of the study was to clarify the mechanisms underlying the increased IL-23 expression in the gut of AS patients.
Accardo Palumbo,A, ALESSANDRO, Riccardo, Cannizzaro, A, CICCIA, Francesco, Colbert, RA, GIARDINA, Annarita, GUGGINO, Giuliana, RAIMONDO, Stefania, Rizzo,A, TRIOLO, Giovanni   +9 more
core   +1 more source

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

Frontiers in Immunology, 2017
Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8+ T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats.
M. V. van Tok, N. Satumtira, M. Dorris, D. Pots, G. Slobodin, M. V. D. van de Sande, J. Taurog, D. Baeten, L. V. van Duivenvoorde   +8 more
semanticscholar   +1 more source

Inmunogenética del HLA-B27

Biomédica, 1990
En los últimos cinco (5) años el avance de la biología molecular ha podido clarificar los subtipos del B27 y así poder estudiar su ontogenia. Esta revisión tiene el propósito de analizar la estructura y función de las moléculas de clase 1, como una unidad funcional en la respuesta inmunitaria y su interacción con el agente en la expresión de la ...
Antonio Iglesias Gamarra, Julio Granados Arriola   +1 more
openaire   +3 more sources