Results 211 to 220 of about 206,002 (249)
Some of the next articles are maybe not open access.
HLA-B27 and immunogenetics of spondyloarthropathies
Current Opinion in Rheumatology, 2000The arthritogenic peptide hypothesis has inspired research aimed at defining the peptide-presenting properties of HLA-B27 subtypes and their relation to ankylosing spondylitis. Various studies have shed new light on the influence of HLA-B27 polymorphism in modulating peptide binding and T-cell antigen presentation.
Iñaki Alvarez +1 more
openaire +3 more sources
Rheumatology, 1988
The various subtypes of HLA-B27 are described together with their worldwide distribution. None is uniquely related to AS but the evidence favours a direct role for B27 in the disease pathogenesis.
openaire +3 more sources
The various subtypes of HLA-B27 are described together with their worldwide distribution. None is uniquely related to AS but the evidence favours a direct role for B27 in the disease pathogenesis.
openaire +3 more sources
Annals of Internal Medicine, 1977
Excerpt To the editor: Esdaile, Dwosh, Urowitz, Smythe, and Falk (1) have reported in this journal a similar frequency of HLA B27 in patients with seronegative rheumatiod arthritis and a control po...
openaire +3 more sources
Excerpt To the editor: Esdaile, Dwosh, Urowitz, Smythe, and Falk (1) have reported in this journal a similar frequency of HLA B27 in patients with seronegative rheumatiod arthritis and a control po...
openaire +3 more sources
HLA-B27 and pathogenesis of spondyloarthropathies
Current Opinion in Rheumatology, 2002Although the influence of HLA-B27 on the development of spondyloarthropathies is undisputed, its role in pathogenesis remains unclear. New ideas have focused on abnormal characteristics of HLA-B27 resulting from aberrant folding, disulfide bond formation, or both, rather than a predilection for selecting arthritogenic peptides.
Robert A. Colbert, Matthew J. Turner
openaire +3 more sources
Immunogenetics, HLA-B27 and spondyloarthropathies
Current Opinion in Rheumatology, 1999HLA-B27 is the strongest HLA molecule associated with a disease. However, the reason only a small fraction of HLA-B27 positive individuals develop spondyloarthropathies is still unknown. Recent advances in genetics support the fact that additional genetic factors influence the disease and that the environmental factors may be ubiquitous.
Carlos López-Larrea +2 more
openaire +3 more sources
HLA-B27 and the Seronegative Spondyloarthropathies
The American Journal of the Medical Sciences, 1998In the 25 years since the initial reports of the association of HLA-B27 with ankylosing spondylitis (AS) and subsequently with Reiter's syndrome, psoriatic spondylitis, and the spondylitis of inflammatory bowel disease, the association of HLA-B27 with the seronegative spondyloarthropathies has remained one of the best examples of a disease association ...
openaire +2 more sources
The Lancet, 1976
Histocompatibility antigens were determined in 38 patients with frozen shoulder and 216 normal blood-donors. HLA-B27 was significantly more common in patients with frozen shoulder (42%) than in the controls (10%). The distribution of the other 19 histocompatibility antigens was similar in the patient and control groups.
B.L. Hazleman, D. Voak, D.Y. Bulgen
openaire +3 more sources
Histocompatibility antigens were determined in 38 patients with frozen shoulder and 216 normal blood-donors. HLA-B27 was significantly more common in patients with frozen shoulder (42%) than in the controls (10%). The distribution of the other 19 histocompatibility antigens was similar in the patient and control groups.
B.L. Hazleman, D. Voak, D.Y. Bulgen
openaire +3 more sources
Neutrophil Function and HLA-B27
Rheumatology, 1983The pathogenesis of HLA-B27 linked diseases, including reactive enteroarthritides, is not known. Differences in immune response, cross-reaction between microbial antigens and host cell structures, attachment of microbial components on the host cell surfaces with subsequent autoimmune reaction, and inflammatory responsiveness of the host may be involved.
O. Laitinen +8 more
openaire +3 more sources
Acute Anterior Uveitis and HLA-B27
Survey of Ophthalmology, 1991Acute anterior uveitis is a common ocular disease characterized by inflammation of the iris and ciliary body. In the majority of patients presenting with an acute attack of anterior uveitis, the only clues to the pathogenesis of this disease are its close association with the genetic marker HLA-B27 and the likely triggering role of a variety of gram ...
John H Chang +6 more
openaire +4 more sources
HLA-B27 as a receptor for cytomegalovirus
Current Eye Research, 1992Acute anterior uveitis (AAU) is strongly associated with the genetic marker and cell membrane protein HLA-B27. Although also other genetic factors must play a pathogenetic role, the HLA-class I molecule B27 is up to now the only hold. The normal task of HLA class I molecules is to present endogenous, mostly viral, peptides to receptors on cytotoxic T ...
Jan L.M.C. Geelen +3 more
openaire +3 more sources