The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients
Frontiers in Medicine, 2021 HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+
Xinyu Wu +10 more
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T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis
Current Rheumatology Reports, 2022 Ankylosing spondylitis (AS) is strongly associated with the HLA-B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 lymphocytes, leading to adaptive immune responses.
J. Garrido-Mesa, M. Brown
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Recent Developments in HLA B27 Anterior Uveitis
Frontiers in Immunology, 2021 There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years.
D. Wakefield, D. Clarke, P. McCluskey
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HLA-B27 is associated with reduced disease activity in axial spondyloarthritis
Scientific Reports, 2021 HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) is apparently the opposite.
James T. Rosenbaum +9 more
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Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
eLife, 2021 Uveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. Uveitis associated with the HLA haplotype B27 (HLA-B27) is a common subtype of uveitis and a prototypical ocular ...
M. Kasper +11 more
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Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis. [PDF]
PLoS ONE, 2013 The development of suitable methods to deliver peptides specifically to the endoplasmic reticulum (ER) can provide some potential therapeutic applications of such peptides.
Hui-Chun Yu +7 more
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Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis. Is a state of relative immunodeficiency pathogenic in HLA B27-positive uveitis? [PDF]
PLoS ONE, 2013 Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated
Gernot Steinwender +6 more
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Clinical picture of ankylosing spondylitis in HLA-B27 positive and negative patients
Современная ревматология, 2023 The link between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for almost 50 years. During this time, it has been discovered that some of the clinical manifestations of the disease are uniformly associated with the disease in almost all
Sh. F. Erdes, K. V. Sakharova
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Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27–positive Male Subjects [PDF]
Journal of Rheumatology, 2017 R. Sengupta +4 more
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Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population. [PDF]
PLoS ONE, 2015 Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS.
James Cheng-Chung Wei +8 more
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