Results 21 to 30 of about 206,002 (249)

Prevalence of spondylarthropathies in HLA‐B27 positive and negative blood donors [PDF]

Arthritis & Rheumatism, 1998
OBJECTIVE To determine the overall prevalence of spondylarthropathy (SpA) among whites. METHODS To screen for SpA symptoms, such as inflammatory back pain (IBP), joint swelling, psoriasis, and uveitis, or a specific family history, questionnaires were ...
Jürgen Braun, Mathias Bollow, Gerold Remlinger, U. Eggens, Martín Rudwaleit, Armin Distler, Joachim Sieper   +6 more
openalex   +2 more sources

Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis. Is a state of relative immunodeficiency pathogenic in HLA B27-positive uveitis? [PDF]

PLoS ONE, 2013
Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated
Gernot Steinwender, Ewald Lindner, Martin Weger, Sophie Plainer, Wilfried Renner, Navid Ardjomand, Yosuf El-Shabrawi   +6 more
doaj   +1 more source

Clinical picture of ankylosing spondylitis in HLA-B27 positive and negative patients

Современная ревматология, 2023
The link between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for almost 50 years. During this time, it has been discovered that some of the clinical manifestations of the disease are uniformly associated with the disease in almost all
Sh. F. Erdes, K. V. Sakharova
doaj   +1 more source

Interaction between HLA-B60 and HLA-B27 as a Better Predictor of Ankylosing Spondylitis in a Taiwanese Population. [PDF]

PLoS ONE, 2015
Ankylosing spondylitis (AS) is a form of chronic inflammatory spondyloarthritis (SpA) that causes pain and stiffness in spines or joints. Human leukocyte antigen B27 (HLA-B27) and B60 (HLA-B60) have been reported as major genetic risk factors of AS.
James Cheng-Chung Wei, Henry Wong Sung-Ching, Yu-Wen Hsu, Ya-Feng Wen, Wen-Chang Wang, Ruey-Hong Wong, Hsing-Fang Lu, Floris A van Gaalen, Wei-Chiao Chang   +8 more
doaj   +1 more source

HLA‑B27 misfolding and spondyloarthropathies [PDF]

Prion, 2009
HLA-B27 plays a central role in the pathogenesis of many spondyloarthropathies and in particular ankylosing spondylitis. The observation that the HLA-B27 heavy chain has a tendency to misfold has raised the possibility that associated diseases may belong in a rapidly expanding category of protein misfolding disorders. The synthesis of the HLA-B27 heavy
Robert A. Colbert, Monica L. DeLay, Gerlinde Layh-Schmitt, Dawn P. Sowders   +3 more
openaire   +5 more sources

The Phenotype of Axial Spondyloarthritis: Is It Dependent on HLA–B27 Status?

Arthritis care & research, 2020
To describe the radiographic phenotype of axial spondyloarthritis (SpA) according to the presence of HLA–B27.
L. Coates, X. Baraliakos, F. Blanco, E. Blanco-Morales, J. Braun, V. Chandran, J. Fernández-Sueiro, O. FitzGerald, P. Gallagher, D. Gladman, E. Gubar, T. Korotaeva, E. Loginova, E. Lubrano, J. Mulero, J. Pinto-Tasende, R. Queiró, J. Sanz Sanz, A. Szentpetery, P. Helliwell   +19 more
semanticscholar   +1 more source

HLA-B27 subtypes in the spondarthropathies [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYThe spondartliropathy (Sp)-associated HLA-B27 antigen includes al least seven subtypes. B*2701–07, of which 01, 02, 05 and 07 occur in Caucasians. This study examined the B27 subtype distribution in British patients with Sp. The 133 HLA-B27+ subjecis comprised 94 European Caucasian Sp (58 ankylosing spondylitis (AS), 22 reactive arlhrilis (ReA ...
R. A. Hughes, A. C. S. Keat, Stella C. Knight, I. L. Maclean, Gabrielle H. Kingsley, S. Iqball, P. Woo   +6 more
openaire   +3 more sources

Treatment Responses in Patients With Psoriatic Arthritis Axial Disease According to Human Leukocyte Antigen‐B27 Status: An Analysis From the CorEvitas Psoriatic Arthritis/Spondyloarthritis Registry

ACR Open Rheumatology, 2022
Objective Axial disease is common and burdensome in patients with psoriatic arthritis (PsA). Human leukocyte antigen‐B27 (HLA‐B27) is a risk factor for axial PsA; treatment response by HLA‐B27 status is inadequately characterized.
Philip J. Mease, Soumya D. Chakravarty, Robert R. McLean, Taylor Blachley, Toana Kawashima, Iris Lin, Arthur Kavanaugh, Alexis Ogdie   +7 more
doaj   +1 more source

Homozygosity For HLA‐B27 [PDF]

Arthritis & Rheumatism, 1977
AbstractThe effect of homozygosity for HLA‐B27 on the clinical expression of rheumatic disease was studied in two families. The 1 homozygous patient in each of two families demonstrated extraordinarily severe peripheral and axial arthritis compared to other affected heterozygous relatives.
Wilma B. Bias, Wilma B. Bias, Bernice Z. Schacter, Bernice Z. Schacter, Marc C. Hochberg, Marc C. Hochberg, Susan H. Hsu, Susan H. Hsu, Frank C. Arnett, Frank C. Arnett   +9 more
openaire   +2 more sources

The Ramifications of HLA-B27 [PDF]

Journal of the Royal Society of Medicine, 2004
Thirty years after its discovery,1,2 the association between HLA-B27 and ankylosing spondylitis remains the strongest known relationship between a major histocompatibility complex (MHC) antigen and a disease. Epidemiological studies in the 1960s and early 1970s identified close links between several distinct forms of arthritis that were given the ...
openaire   +3 more sources