Results 41 to 50 of about 116,043 (221)

Characterisation of the oxidoreductase Erol-Lß and the misfolding of the secretory pathway substrate HLA-B27 [PDF]

, 2007
The endoplasmic reticulum (ER) is the site of oxidative folding for proteins entering the secretory pathway. Here, nascent polypeptides acquire disulfide bonds, which confer both stability and functionality on secretory and ER-resident proteins.
Lemin, Andrew James
core  

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

HLA-B27 aikuisten uveiitissa [PDF]

, 2021
Tiivistelmä. Uveiitti on silmän suonikalvoston tulehdus. Suurin osa uveiiteista on anatomisesti anteriorisia. Uveiitti on harvinaisuudestaan huolimatta merkittävä sokeuden ja näkövammautumisen syy.
Leino, A. (Aada)
core   +2 more sources

Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

Arthritis Research & Therapy, 2018
Objective To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed.
Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes, Pilar Font, REGISPONSER group   +11 more
doaj   +1 more source

Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis Within a Longitudinal Cohort

Arthritis &Rheumatology, EarlyView.
Objective The purpose of this study was to estimate the prevalence of difficult‐to‐manage (D2M) and treatment‐refractory (TR) axial spondyloarthritis (axSpA) and to identify factors associated with D2M and TR disease in a longitudinal cohort. Methods We performed a cross‐sectional analysis on data from the Schroeder Arthritis Institute Spondylitis ...
Patricia Remalante‐Rayco, Laura Passalent, Tina Chim, Hannah Vijayan, Manal Alnasser, Zeynep Baskurt, Robert D. Inman, Nigil Haroon, Denis Poddubnyy   +8 more
wiley   +1 more source

Seronegative spondyloarthropathies : a review : part II: genetics and pathogenesis [PDF]

, 1993
In none of the spondyloarthropathies is the pathogenesis well understood. Much of the investigation into the aetio-pathogenesis of these diseases has focused on the association with HLA-B27 and the known triggering potential of certain infectious agents.
Borg, Andrew A., Hothersall, T.E., Dawes, Peter T.   +2 more
core  

Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells. [PDF]

PLoS ONE, 2013
A tissue antigen, HLA-B27, is strongly associated with a group of rheumatic diseases called spondyloarthritides. Despite the intensive research, the exact role of HLA-B27 in the pathogenesis of these diseases is still unclear. Here we studied whether HLA-
Marja Ruuska, Anna S Sahlberg, Kaisa Granfors, Markus A Penttinen   +3 more
doaj   +1 more source

HLA-B27, axial spondyloarthritis and survival

, 2023
INTRODUCTION Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality. We evaluated this hypothesis, using data from both a 35-year AS follow-up study and UK Biobank
Li, Zhixiu, Winkens, Bjorn; id_orcid, Winkens, Bjorn, Muhammad Asim Khan, Baumberger, Heinz, Heinz Baumberger, Zhixiu Li, Van Der Linden, Sjef M., Khan, Muhammad Asim, Bjorn Winkens, Sjef M van der Linden, Khan, Mohammad Kazim, Villiger, Peter M, Brown, Matthew A., Peter M Villiger, van Zandwijk, Hermine, van der Linden, Sjef M, Brown, Matthew A, Matthew A Brown, Hermine van Zandwijk, Villiger, Peter M., Mohammad Kazim Khan, https://orcid.org/   +22 more
core   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

HLA-B27 frequency in a group of patients with psoriatic arthritis Freqüência de HLA-B27 em uma amostra de pacientes com artrite psoriática

Anais Brasileiros de Dermatologia, 2012
BACKGROUND: HLA-B27 is associated with spondyloarthritis, a group of diseases that includes psoriatic arthritis. OBJECTIVES: To describe the HLA-B27 frequency in a group of Brazilian patients with psoriatic arthritis and correlate its presence or absence
Danilo Garcia Ruiz, Mário Newton Leitão de Azevedo, Omar Lupi   +2 more
doaj   +1 more source