Results 51 to 60 of about 116,043 (221)

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis

, 2006
Objective: To determine the influence of HLA-B27 homozygosity and HLA-DRB1 alleles in the susceptibility to, and severity of, ankylosing spondylitis in a Finnish population.
Pointon, JJ, Herzberg, I., Tuomilehto, J, Tuomilehto-Wolf, E., Laiho, Kari, Herzberg, Ibi, Jaakkola, E, Laiho, K., Barnardo, M. C. N. M., Jaakkola, E., Laiho, K, Brown, Matthew A., Tuomilehto, J., Wordsworth, B. P., Pointon, Jennifer J., Wordsworth, B. Paul, Wordsworth, Bryan, Kaarela, Kalevi, Herzberg, I, Kauppi, M, Kaarela, K., Barnardo, MC, Jaakkola, Elisa, Brown, M A, Kaarela, K, Kauppi, Markku, Tuomilehto-Wolf, E, Brown, MA, Kauppi, M., Wordsworth, BP, Tuomilehto-Wolf, Eva, Pointon, J. J., Barnardo, Martin C.N.M., Tuomilehto, Jaakko   +33 more
core   +1 more source

Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker

Kurdistan Journal of Applied Research
Rheumatoid arthritis (RA) is a predominant inflammatory arthritis in human. The function of HLA-B27 gene in other types of arthritis has been studied, however, its function in RA is unclear. This study investigated the relative expression of HLA-B27 gene
Karzan Ghafur Khidhir, Baban Ahmad, Dana Khdr Sabir   +2 more
doaj   +1 more source

Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy

Frontiers in Immunology, 2021
Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the
Tejpal Gill, James T. Rosenbaum, James T. Rosenbaum   +2 more
doaj   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, EarlyView.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

Prognostic prediction models for psoriatic arthritis in psoriasis: A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review evaluated prognostic prediction models used to assess the risk of future psoriatic arthritis in psoriasis patients. The included studies reported modest to moderate performance measures, with limited external validation, inadequate reporting and high risk of bias.
Fatimah Khoda, Yasmin Khan, William W. Y. Haw, Sayeda Nahar, Claire Hodkinson, Hector Chinoy, Richard B. Warren, Glen P. Martin, Zenas Z. N. Yiu   +8 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Adverse events in patients with HLA-B27-associated uveitis receiving systemic treatments.

, 2020
Adverse events in patients with HLA-B27-associated uveitis receiving systemic treatments.
Pierre Pradat (816487), Roland Chapurlat (283094), Nabil Bouzid (8648571), Laurent Kodjikian (5488115), Yvan Jamilloux (436733), Audrey De Parisot (8648574), Pascal Sève (4449340)   +6 more
core   +1 more source

Association of ERAP2 polymorphisms in Colombian HLA-B27+ or HLA-B15+ patients with SpA and its relationship with clinical presentation: axial or peripheral predominance

RMD Open, 2020
Objective To determine the association between endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single-nucleotide polymorphisms (SNPs) and human leukocyte antigens (HLA)-B27+ or HLA-B15+ patients with spondyloarthritis (SpA).Methods 104 patients ...
Ruben Burgos-Vargas, John Londono, Ana M Santos, Juan C Rueda, Enrique Calvo-Paramo, Gilberto Vargas-Alarcon, Nancy Martinez-Rodriguez, Sofia Arias-Correal, Guisselle-Nathalia Muñoz, Diana Padilla, Francy Cuervo, Viviana Reyes-Martinez, Santiago Bernal-Macías, Catalina Villota-Eraso, Luz M Avila-Portillo, Consuelo Romero, Juan F Medina   +16 more
doaj   +1 more source

Human Leukocyte Antigen B27‐Negative Axial Spondyloarthritis: What Do We Know?

ACR Open Rheumatology, 2023
Axial spondyloarthritis (axSpA) is a chronic, immune‐mediated disease characterized by inflammatory axial skeleton involvement and extra‐musculoskeletal manifestations.
Atul Deodhar, Tejpal Gill, Marina Magrey
doaj   +1 more source