Results 81 to 90 of about 206,002 (249)

Arthritis in Cystic Fibrosis—Comparison of a Single‐Center Cohort and Published Case Reports/Series and a Review of the Literature

APMIS, Volume 133, Issue 8, August 2025.
ABSTRACT Cystic fibrosis (CF) is commonly associated with musculoskeletal issues including inflammatory arthritis, CF arthritis. We present a retrospective cohort study which aims to describe the clinical characteristics, prevalence, and demographic associations of CF arthritis using both a clinical and literature cohort.
Anne Sofie Rosenborg Peretz, Thomas Bryrup, Daniel Faurholt‐Jepsen, Christoffer Tandrup Holst Nielsen   +3 more
wiley   +1 more source

Adalimumab Monotherapy or Combination Therapy With Methotrexate in Paediatric Uveitis: Data From the AIDA Network Uveitis Registry

Clinical &Experimental Ophthalmology, Volume 53, Issue 6, Page 619-626, August 2025.
ABSTRACT Background The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU). Methods Registry‐based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus ...
Carla Gaggiano, Alejandra de‐la‐Torre, Silvana Guerriero, Stefania Costi, Gaafar Ragab, Maria Pia Paroli, Emanuela Del Giudice, Luciana Breda, Saverio La Bella, Marco Cattalini, Maria Cristina Maggio, Alex Fonollosa, Ester Carreño, Maria Tarsia, Rosanna Dammacco, Soad Hashad, Antonio Vitale, Lampros Fotis, Stefano Gentileschi, Francesca Minoia, Germán Mejía‐Salgado, Halah Etayari, Paola Saboya‐Galindo, María Andrea Bernal‐Valencia, Adele Civino, Maria Sole Chimenti, Valeria Caggiano, Maria Francesca Gicchino, Jurgen Sota, Angela Mauro, Giuseppe Lopalco, Kalpana Babu Murthy, Mohamed Tharwat Hegazy, Vishali Gupta, Francesco La Torre, Rana Hussein Amin, Bruno Frediani, Gian Marco Tosi, Luca Cantarini, Claudia Fabiani, on behalf of the AIDA Network   +40 more
wiley   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source

Sex‐Related Differences in Efficacy and Safety Outcomes in Axial Spondyloarthritis Randomized Clinical Trials: A Systematic Literature Review and Meta‐Analysis

Arthritis Care &Research, Volume 77, Issue 7, Page 813-826, July 2025.
Objective We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs). Methods We conducted a systematic literature search for RCTs assessing the efficacy of advanced therapies in patients with axSpA ...
Angel Gao, Jordi Pardo Pardo, Steven Dang, Lianne S. Gensler, Philip Mease, Lihi Eder   +5 more
wiley   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, Volume 12, Issue 26, July 10, 2025.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats

Journal of Experimental Medicine, 1994
A number of inflammatory disease states occur with greatly increased frequency in individuals inheriting the human major histocompatibility complex class I allele HLA-B27. In a minority of cases, namely those with B27-associated reactive arthritis, there
J. Taurog, J. Richardson, JoAnne T. Croft, W. Simmons, W. Simmons, Ming Zhou, Ming Zhou, J. Fernández-Sueiro, E. Balish, R. Hammer   +9 more
semanticscholar   +1 more source

Functional Synovium‐Based 3D Models in the Context of Human Disease and Inflammation

Advanced NanoBiomed Research, Volume 5, Issue 7, July 2025.
The synovium is key to joint function but is often affected by diseases like rheumatoid arthritis. Finding better treatments is challenging because current lab models do not fully mimic real tissues. New 3D technologies, like bioprinting, offer better methods to study these diseases, improve drug testing, and develop personalized treatments, bringing ...
Amelia Heslington, Catharien M. U. Hilkens, Ana Marina Ferreira, Priscila Melo   +3 more
wiley   +1 more source

Avaliação clínica, laboratorial e radiográfica de brasileiros com espondiloartropatias Clinical, laboratorial and radiographic evaluation in Brazilians with spondyloarthropaties

Revista Brasileira de Reumatologia, 2006
OBJETIVO: analisar o padrão de doença de pacientes brasileiros com espondiloartropatias (EAP). PACIENTES E MÉTODOS: foram avaliados 156 pacientes por meio de análise descritiva e análise de associação uni e multivariada entre a distribuição das ...
Carlos Alexandre de Souza Bomtempo, Ricardo da Cruz Lage, Gilda Aparecida Ferreira, Marco Antonio Parreiras de Carvalho   +3 more
doaj   +1 more source

HLA-B27 and psoriatic disease: a modern view of an old relationship.

Rheumatology, 2016
Psoriasis and PsA are the main phenotypes of psoriatic disease. Both conditions are highly polygenic diseases in which stochastic and environmental factors are crucial in the pathogenic process.
R. Queiró, I. Morante, I. Cabezas, B. Acasuso   +3 more
semanticscholar   +1 more source

HLA-B27: what's new? [PDF]

Rheumatology, 2010
The HLA-B27 molecule is one of the most fascinating in medicine. Its contribution to the aetiopathogenesis of SpA and other diseases, and its protective action in certain infections, continue to challenge our understanding of its immunobiology and physiological roles. Animal studies have helped to cast light on ways in which HLA-B27 exerts its effects.
openaire   +3 more sources