Results 101 to 110 of about 93,215 (258)

Reactive Arthritis: From Clinical Features to Pathogenesis [PDF]

open access: yes, 2013
Reactive arthritis (ReA) is a sterile synovitis which occurs after a gastrointestinal or urogenital infection. ReA belongs to pondyloarthritis (SpA), a group of diseases that share several clinical and radiological features including familiar clustering,
Cargnelutti, Ethelina   +1 more
core   +2 more sources

Clinical Spectrum of HLA-B27-associated Ocular Inflammation

open access: yesOcular immunology and inflammation, 2017
Human leukocyte antigen (HLA)-B27-associated anterior uveitis (AU) is the most commonly diagnosed form of AU and represents the largest entity of non-infectious uveitis around the world.
K. Pathanapitoon   +3 more
semanticscholar   +1 more source

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

open access: yesOrthopaedic Surgery, Volume 17, Issue 6, Page 1561-1576, June 2025.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia   +7 more
wiley   +1 more source

Antigen HLA-B27 i ankilozantni spondilitis.

open access: yesVojnosanitetski pregled, 1983
Antigen HLA-B27 i ankilozantni spondilitis.
Bastasić, M   +2 more
openaire   +2 more sources

Evidence for Altered Cytoskeleton Mobilization Pathway in Splenic Dendritic Cells (DC) from HLA-B27/human b2 microglobulin Transgenic Rats (B27-rats) [PDF]

open access: yes, 2008
Background: Although the association of the MHC class I allele HLA-B27 with Spondyloarthropathy (SpA) has been known for almost 35 years different hypotheses on its relation to disease mechanism still exist in parallel.
André, Claudine   +8 more
core   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 5, Page 1043-1053, May 2025.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang   +9 more
wiley   +1 more source

Autologous Peripheral Vγ9Vδ2 T Cell Synergizes with αβ T Cell Through Antigen Presentation and BTN3A1 Blockade in Immunotherapy of Cervical Cancer

open access: yesAdvanced Science, Volume 12, Issue 18, May 15, 2025.
This study provides proof‐of‐concept evidence showing that through direct killing, antigen presentation, and competitively binding to BTN3A1, Vγ9Vδ2 T cells amplified from cervical cancer (CC) patients can synergize with αβ T cells to exert anti‐CC function both in vitro and in vivo.
Min Wu   +21 more
wiley   +1 more source

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. [PDF]

open access: yes, 2003
CD8+ class I-restricted cytotoxic T lymphocytes (CTLs) usually incompletely suppress HIV-1 in vivo, and while analogous partial suppression induces antiretroviral drug-resistance mutations, epitope escape mutations are inconsistently observed.
Ali, Ayub   +6 more
core  

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

open access: yesAdvanced Science, Volume 12, Issue 19, May 22, 2025.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li   +8 more
wiley   +1 more source

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