Results 111 to 120 of about 1,839,216 (336)

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. [PDF]

, 2019
BackgroundRapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs ...
Goldstein RE, Grauer GF, Kalish RA, Levy S, Levy SA, Rolla D, Scorpio DG   +6 more
core   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function — The Ulm-Frankfurt population study [PDF]

, 1991
Out of a random population of 4208 non-diabetic pupils without a family history of Type I diabetes 44 (1.05%) individuals had islet cell antibody (ICA) levels greater or equal to 5 Juvenile Diabetes Foundation (JDF) units. 39 of these ICA-positives could
AC Tarn, AG Ziegler, AG Ziegler, B Kuglin, B Kuglin, B. O. Boehm, BM Dean, C Betterle, E Bonifacio, E. F. Pfeiffer, E. Heinze, GS Eisenbarth, J Bertrams, J Karjalainen, J Karjalainen, J. Seißler, JJ Rood Van, JP Palmer, KM Spencer, M Bergua, M. Glück, MA Atkinson, N. Yassin, P Vardi, S Srikanta, S Srikanta, SA Arslanian, T Wilkin, W. A. Scherbaum, WA Scherbaum   +29 more
core   +1 more source

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms

Diabetes, 2013
Evaluating risk of developing type 1 diabetes (T1D) depends on determining an individual’s HLA type, especially of the HLA DRB1 and DQB1 alleles. Individuals positive for HLA-DRB1*03 (DR3) or HLA-DRB1*04 (DR4) with DQB1*03:02 (DQ8) have the highest risk ...
Cao Nguyen, M. Varney, L. Harrison, G. Morahan   +3 more
semanticscholar   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target

Frontiers in Endocrinology
ObjectiveIncreasing evidence has suggested that immune cells are known to play a pivotal role in the progression of diabetic nephropathy (DN). However, the specific causal role of monocyte surface markers, particularly human leukocyte antigen-DR (HLA-DR),
Yue Wang, Shaojie Fu, Sensen Su, Zhonggao Xu   +3 more
doaj   +1 more source

Aberrant HLA-DR expression in the conjunctival epithelium after autologous serum treatment in patients with graft-versus-host disease or Sjögren's syndrome.

PLoS ONE, 2020
The aim of this study was to determine the effect of autologous serum (AS) eye drops on the density of human leucocyte antigen (HLA)-DR-positive epithelial cells and Langerhans cells on the ocular surface of patients with bilateral severe dry eye disease
Katerina Jirsova, Petra Seidler Stangova, Michalis Palos, Gabriela Mahelkova, Sarka Kalasova, Ivana Rybickova, Tor Paaske Utheim, Viera Vesela   +7 more
doaj   +1 more source

Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]

, 2019
OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte, Bottcher, Chan, Chayanupatkul, Chiba, Corbett, Cosgrove, Degre, Dhanda, Dusseaux, Eckle, Fergusson, Fung, Gao, Gao, Gerart, Hegde, Hengst, Jampana, Jeffery, Jiang, Kjer-Nielsen, Kurioka, Leclercq, Leeansyah, Leeansyah, Li, Liangpunsakul, Liangpunsakul, Loh, Markwick, Mutlu, Nagy, O'Shea, Pasala, Patel, Puri, Rao, Reantragoon, Riva, Saberi, Slichter, Spaan, Tang, Tilloy, Ussher, van Wilgenburg, Wong, Yong   +48 more
core   +1 more source

A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.

Arthritis & Rheumatism, 2004
OBJECTIVE The main genetic risk factor for rheumatoid arthritis (RA) is the shared epitope (SE) of HLA-DR, while smoking is an important environmental risk factor.
L. Padyukov, Camilla Silva, P. Stolt, L. Alfredsson, L. Klareskog   +4 more
semanticscholar   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source