Results 1 to 10 of about 71,364 (318)

Human leukocyte antigen variation among Iranian renal transplant recipients [PDF]

Journal of Nephropathology, 2012
Background: HLA typing analysis is important in renal transplant patients. Objectives: We made a plan to determine the most frequent HLA antigens in Iranian kidney transplant patients.
Behzad Einollahi, Zohreh Rostami, Mojtaba Teimoori   +2 more
doaj   +1 more source

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses

Cell Reports, 2023
Summary: Subunit vaccines typically require co-administration with an adjuvant to elicit protective immunity, adding development hurdles that can impede rapid pandemic responses.
Audrey Kassardjian, Eric Sun, Jamie Sookhoo, Krithika Muthuraman, Kayluz Frias Boligan, Iga Kucharska, Edurne Rujas, Arif Jetha, Donald R. Branch, Shawn Babiuk, Brian Barber, Jean-Philippe Julien   +11 more
doaj   +1 more source

Current research status of HLA in immune‐related diseases

Immunity, Inflammation and Disease, 2021
Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas.
Bingnan Liu, Yuanyuan Shao, Rong Fu
doaj   +1 more source

Comprehensive Analysis of CD4+ T Cell Response Cross-Reactive to SARS-CoV-2 Antigens at the Single Allele Level of HLA Class II

Frontiers in Immunology, 2022
Common human coronaviruses have been circulating undiagnosed worldwide. These common human coronaviruses share partial sequence homology with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, T cells specific to human coronaviruses
You-Seok Hyun, You-Seok Hyun, Yong-Hun Lee, Yong-Hun Lee, Hyeong-A Jo, Hyeong-A Jo, In-Cheol Baek, Sun-Mi Kim, Hyun-Jung Sohn, Tai-Gyu Kim, Tai-Gyu Kim, Tai-Gyu Kim   +11 more
doaj   +1 more source

Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4+ T cell responses restricted by single HLA class II allotype in an individual

Frontiers in Immunology, 2022
Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world’s leading bacterial cause of death.
Yong-Hun Lee, Yong-Hun Lee, You-Seok Hyun, You-Seok Hyun, Hyeong-A Jo, Hyeong-A Jo, In-Cheol Baek, Sun-Mi Kim, Hyun-Jung Sohn, Tai-Gyu Kim, Tai-Gyu Kim, Tai-Gyu Kim   +11 more
doaj   +1 more source

PECULIARITIES OF HLA-PHENOTYPES IN PATIENTS WITH PYELONEPHRITIS [PDF]

Annals of Mechnikov's Institute, 2016
Introduction. Of great interest are the studies on the role of human leucocyte antigens (HLA) in pathogenesis of a disease. The kidneys is vulnerable to injury in the context of inflammatory responses, with the potential involvement of a number of ...
Haiseniuk F, Driyanska V, Kruglikov V
doaj   +1 more source

Study of HLA-A and HLA-DR Polymorphism in Local Population, Pakistan

TSF Journal of Biology, 2023
The compatibility of human leukocyte antigen (HLA) between donor and recipient is a major threat during kidney transplantation. HLA alleles are highly diverse among different individuals of the same population.
Khizra Aslam, Rabbia Jawad, Khurram Liaqat   +2 more
doaj   +1 more source

Peculiarities of phenotypes of patients with pyelo- and glomerulonephritis by HLA distribution analysis

Український Журнал Нефрології та Діалізу, 2018
Studies devoted to the role of human leucocyte antigens (HLA) in pathogenesis of chronic kidney disease (CKD) have demonstrated the associative links of the HLA antigens, which stipulate the relative and attributive risks of some autoimmune diseases ...
V. Driianska, O. Petrina, M. Velychko, F. Haisenyuk, G. Drannik   +4 more
doaj   +1 more source

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Journal of Immunology Research, 2017
The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the ...
Vadim Jucaud
doaj   +1 more source

Donor HLA−DR Drives the Development of De Novo Autoimmunity Following Lung and Heart Transplantation

Transplantation Direct, 2020
Background. Individuals harbor preexisting HLA−DR/DQ−restricted responses to collagen type V (ColV) mediated by Th17 cells under Treg control, both specific to peptides that bind to inherited HLA class II antigens. Yet after transplant, the donor−DR type
Ewa Jankowska−Gan, MS, Vrushali V. Agashe, PhD, Diego A. Lema, MD, Ying Zhou, MS, Laura Gonzalez Bosc, PhD, Jeremy A. Sullivan, PhD, Daniel S. Greenspan, PhD, William J. Burlingham, PhD   +7 more
doaj   +1 more source