Results 251 to 260 of about 1,839,216 (336)

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

Annals of Neurology, Volume 99, Issue 2, Page 492-501, February 2026.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross   +34 more
wiley   +1 more source

ANXA10 sensitizes microsatellite instability-high colorectal cancer to anti-PD-1 immunotherapy via assembly of HLA-DR dimers by regulating CD74. [PDF]

Cell Biol Toxicol
Sun Y, Yang B, Wen T, Guo X, Li D, Shi R, Zhang F, Wang D, Li C, Qu X.   +9 more
europepmc   +1 more source

Modulating the Gut Microbiome as a Therapeutic Approach in Multiple Sclerosis: Implications for Gut‐Brain Interactions and Immune Pathways: A Narrative Review

Brain and Behavior, Volume 16, Issue 2, February 2026.
The gut microbiome in multiple sclerosis (MS) shows consistent depletion of short‐chain fatty acid (SCFA)‐producing bacteria, expansion of pro‐inflammatory species, and reduced levels of butyrate, propionate, and indole metabolites. These alterations increase intestinal permeability, disrupt immune balance, and contribute to blood–brain barrier ...
Husna Irfan Thalib, Nuha Fatima, Faaleha Heba Fakruddin, Hosna Hamidullah Ali, Sariya Khan, Mohammed Talha Mohammed Zubair, Mable Pereira, Fatma E. Sayed Hassan   +7 more
wiley   +1 more source

Therapy‐Related Acute Myeloid Leukemia Following Plasma Cell Leukemia: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT With the improvement of survival in multiple myeloma (MM), therapy‐related acute myeloid leukemia (t‐AML) has emerged as a clinically relevant second primary malignancy (SPM). We report a case of MM evolving into t‐AML after multi‐agent chemotherapy and review the literature on therapy‐related leukemias in MM.
Songdi Chen, Junqing Hu, Qian Zhang, Luling Mao, Qian Jiang, Chuyun Qian, Weize Zhang, Keting Jin, Jianhu Li, Ji‐nuo Wang, Yi Zhao   +10 more
wiley   +1 more source

Mediating role of chiro-inositol metabolites on the effects of HLA-DR-expressing CD14 + monocytes in inflammatory bowel disease. [PDF]

BMC Gastroenterol
Zhang L, Shen P, Ge W, Liao W, Luo Q, Li C, Zhan C, Yuan X, Zhang X, Yan X.   +9 more
europepmc   +1 more source

Auer Rod‐Like Inclusions in Chronic Lymphocytic Leukemia: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Auer rod‐like inclusions may occasionally be observed in chronic lymphocytic leukemia. Their recognition on peripheral smear highlights the importance of meticulous morphology assessment when comprehensive hematologic testing cannot be performed.
Tingting Zhang, Linjun Xie
wiley   +1 more source

A Systematic Review and Meta-Analysis of Human Leukocyte Antigen-DR (HLA-DR) in Onychomycosis: HLA-DR8 Confers Susceptibility. [PDF]

Cureus
Cook AC, Cohen NE, Patel R, South S, Ballantyne MC.   +4 more
europepmc   +1 more source

WRAP53 is Downregulated in Acute Myeloid Leukemia Patients and Positively Correlates With HTERT Expression

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Acute myeloid leukemia (AML) is a prevalent hematologic malignancy in adults, marked by clonal disorders in hematopoietic cells, rapid progression, and genetic heterogeneity. The WRAP53 gene, which is associated with genomic stability due to its involvement in activities, such as DNA repair, TP53 regulation, and association with ...
Renan Brito Gadelha, Beatriz Maria Dias Nogueira, Caio Bezerra Machado, Flávia Melo Cunha de Pinho Pessoa, Anna Karolyna da Costa Machado, Germison Silva Lopes, Paulo Henrique Silva Rodrigues, Henrique Girão Martins, Deivide de Sousa Oliveira, Rodrigo Monteiro Ribeiro, Ricardo Parente Garcia Vieira, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, André Salim Khayat, Caroline Aquino Moreira‐Nunes   +14 more
wiley   +1 more source

Electronic Patient File‐Embedded Model‐Informed Precision Dosing Compared with Physician Dosing of Tacrolimus in Kidney Transplantation

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 381-392, February 2026.
Model‐informed precision dosing (MIPD) of tacrolimus in renal allograft recipients, evaluated in silico, demonstrated improved (time to and) probability of target concentration attainment and smaller deviations from target range. Using simulated tacrolimus concentration‐time profiles, a study of 200 patients was predicted to have sufficient power to ...
Dirk R.J. Kuypers, Pieter Annaert, Borefore Jallah, Maarten Naesens, Maxine Teuns, Annouschka Laenen, Ruben Faelens   +6 more
wiley   +1 more source