Results 181 to 190 of about 171,039 (261)

Analysis of HLA-G 14 bp Insertion/Deletion Polymorphism and HLA-G, ILT2 and ILT4 Expression in Head and Neck Squamous Cell Carcinoma Patients. [PDF]

Diseases
Durmanova V, Tedla M, Rada D, Bandzuchova H, Kuba D, Suchankova M, Ocenasova A, Bucova M.   +7 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

HLA-G expression associates with immune evasion muscle-invasive urothelial cancer and drives prognostic relevance. [PDF]

Front Immunol
Branz A, Matek C, Lange F, Bahlinger V, Klümper N, Hölzel M, Strissel PL, Strick R, Sikic D, Wach S, Taubert H, Wullich B, Hartmann A, Seliger B, Eckstein M.   +14 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Homozygous AA Genotype of IL-17A and 14-bp Insertion Polymorphism in HLA-G 3'UTR Are Associated with Increased Risk of Gestational Diabetes Mellitus. [PDF]

Int J Environ Res Public Health
de Souza ATB, Lucas CR, de Carvalho KTC, Neta APR, Bernardes-Oliveira E, Camargo JDAS, Luchessi AD, Cobucci RN, Crispim JCO.   +8 more
europepmc   +1 more source

Hematological Inflammation Indices Are Associated With Active Uveitis in Ankylosing Spondylitis

Journal of Clinical Laboratory Analysis, EarlyView.
Hematological inflammation indices reflect the systemic inflammatory burden in ankylosing spondylitis. Patients with active uveitis exhibit a distinct pro‐inflammatory profile characterised by increased NLR, PLR, SII, SIRI, and AISI, along with decreased HALP and CALLY scores.
Mesude Seda Aydoğdu, Zarife Ekici Gök
wiley   +1 more source

PGRMC2 and HLA-G regulate immune homeostasis in a microphysiological model of human maternal-fetal membrane interface. [PDF]

Commun Biol
Lintao RCV, Richardson LS, Kammala AK, Chapa J, Yunque-Yap DA, Khanipov K, Golovko G, Dalmacio LMM, Menon R.   +8 more
europepmc   +1 more source

A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross‐Reactive Groups and Human Platelet Antigens

Journal of Clinical Laboratory Analysis, EarlyView.
This assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Huimin Ji, Kaihao Feng, Yunping Xu, Le Chang, Ying Yan, Jie Ma, Yi Liu, Jinfeng Zeng, Huizhen Sun, Lunan Wang   +9 more
wiley   +1 more source

LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. [PDF]

EMBO Mol Med
Wang J, Chai Q, Lei Z, Wang Y, He J, Ge P, Lu Z, Qiang L, Zhao D, Yu S, Qiu C, Zhong Y, Li BX, Zhang L, Pang Y, Gao GF, Liu CH.   +16 more
europepmc   +1 more source

Heterogeneous outcomes in pediatric potential celiac disease: A multicenter longitudinal study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Potential celiac disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to study the outcome of children with PCD consuming a gluten‐containing diet (GCD) over time. Methods Children diagnosed with PCD between December 2018 and January 2022, in three pediatric gastroenterology centers, were ...
Barak Laxer, Firas Rinawi, Nadya Ziv‐Sokolovskaya, Raanan Shamir, Michal Kori, Anat Guz‐Mark   +5 more
wiley   +1 more source