Results 141 to 150 of about 106,774 (312)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Immunologic aspects of preeclampsiaAJOG Global Reports at a Glance

AJOG Global Reports
Preeclampsia is a syndrome with multiple etiologies. The diagnosis can be made without proteinuria in the presence of dysfunction of at least 1 organ associated with hypertension. The common pathophysiological pathway includes endothelial cell activation,
Henri Boulanger, MD, Stéphane Bounan, MD, Amel Mahdhi, MD, Dominique Drouin, MD, Salima Ahriz-Saksi, MD, Fabien Guimiot, PhD, Nathalie Rouas-Freiss, PD, PhD   +6 more
doaj   +1 more source

HLA-G may predict the disease course in patients with early arthritis

, 2012
The current management of early arthritis (EA) with negative prognostic factors is to start an intensive treatment. To avoid under/overtreatment, it is important to identify EA evolution biomarkers.
RIZZO, Roberta, FARINA, Ilaria, CIANCIO, GIovanni, DI LUCA, Dario, G. Ciancio, GALUPPI, Elisa, BORTOLOTTI, Daria, GOVONI, Marcello   +7 more
core  

Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing

, 1988
Krämer A, Herth D, von Keyserlingk H, et al. Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift.
Sommer, D., Ludwig, W. D., Hampl, Hartmut, Riecken, Ernst-Otto, Krämer, Alexander ; https://orcid.org/, Hahn, E. G., von Keyserlingk, H., Herth, D.   +7 more
core   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

HLA class-I-transgenic mice as model system to study MHC-restricted antigen recognition in man [PDF]

, 1990
McMichael, A., G. Riethmüller, A. McMichael, Kievits, F., F. Kievits, G. Brem, Ivanyi, P., C. Botteron, Riethmüller, Gert, Botteron, C., P. Ivanyi, Brem, Gottfried, E. H. Weiss, Schliesser, G., G. Schliesser, Weiss, Elisabeth H.   +15 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Assessment of TWIST1 as an immunotherapeutic target of cancer

, 2011
CD8+ T lymphocytes are key mediators of anti-tumour immunity, eliminating tumour cells through the recognition of tumour antigens. Increasing the number of characterised tumour antigens, especially those with highly specific tumour expression, may enable
Poon, E.C.C.
core  

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source