Results 291 to 300 of about 676,827 (333)

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

HLA

THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN, 1984
openaire   +2 more sources

Identifying Genetic Factors Influencing the Development of Anti-Drug Antibodies in Inflammatory Bowel Disease: A Scoping Review. [PDF]

J Inflamm Res
Culmsee-Holm FB, Buhl E, Kraaer MT, Steenholdt C, Ainsworth MA.   +4 more
europepmc   +1 more source

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies. [PDF]

Front Immunol
Beli X, Savvopoulos N, Kefala D, Lysandrou M, Liga M, Spyridonidis A.   +5 more
europepmc   +1 more source

Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma

Q. Li, Huaxiao Yu, Dongyi Ling, Jie Zhou, S M Zhen, Yangyang Li, Lijuan Wang, Zechang Zheng, Wen‐Jian Cen, Hong-Yi Gao, Hui Chen, Jack L. Strominger, Ziming Du   +12 more
openalex   +1 more source

Health economic considerations for pharmacogenomic services in the United Kingdom: The Centre for Excellence in Regulatory Science and Innovation in Pharmacogenomics

British Journal of Clinical Pharmacology, EarlyView.
Dyfrig A. Hughes, Henry Fong, Grace Hampson, Catrin O. Plumpton, Chris Sampson   +4 more
wiley   +1 more source

HLA and T-Cell Receptor Investigations in Idiopathic and Paraneoplastic Opsoclonus-Myoclonus in Children. [PDF]

Neurol Neuroimmunol Neuroinflamm
Olivé-Cirera G, Muñoz-Sánchez G, Palou E, Ruiz García R, Fonseca EG, Luchoro JF, Aguilera-Albesa S, Maudes E, Martinez-Hernandez E, Sabater L, Dalmau JO, González A, Armangue T.   +12 more
europepmc   +1 more source

Increased HLA-DR Expression on M2a Monocytes and Helper T Cells in Patients with COPD and Asthma-COPD Overlap Contributes to Disease Severity via Apoptosis and ROS. [PDF]

Antioxidants (Basel)
Chen YC, Huang KT, Lee CP, Hsu PY, Chang YP, Wu CC, Leung SY, Hsiao CC, Lin MC.   +8 more
europepmc   +1 more source

HLA class-I genotyping to personalize Bacille Calmette-Guerin immunotherapy in bladder cancer. [PDF]

Oncoimmunology
Ruiz-Lorente I, Gimeno L, López-Abad A, Cubillana PL, Aparicio TF, Egea LJA, Avilés JM, Iñiguez GD, Martínez-Valls PLG, Server G, Ferri B, Campillo JA, Galindo F, Martínez-Sánchez MV, Minguela A.   +14 more
europepmc   +1 more source

Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score. [PDF]

Diabetes
Deutsch AJ, Bell AS, Michalek DA, Burkholder AB, Nam S, Kreienkamp RJ, Sharp SA, Huerta-Chagoya A, Mandla R, Nanjala R, Luo Y, Oram RA, Florez JC, Onengut-Gumuscu S, Rich SS, Ng MCY, Motsinger-Reif AA, Manning AK, Mercader JM, Udler MS.   +19 more
europepmc   +1 more source