Results 71 to 80 of about 401,649 (316)

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

, 2001
The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA- associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL ...
Lill, JR, Christmas, SE, Wang, LH, Macintyre, AR, Bourdon, A, Hill, SC, Rojas, J, Dodi, IA, Bonner, PLR, Aubert, G, Creaser, CS, Clark, RE, Rees, RC, Travers, PJ, Madrigal, JA   +14 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.

, 2016
HLA-A~HLA-H~ HLA-G UTRs haplotypes with a frequency greater than 1%.
Julie Di Cristofaro (473988), Jacques Chiaroni (473993), Audrey Tous (3192987), Stéphane Buhler (149592), Virginia Ferreira (3192984), Céline René (10829), Jean-François Eliaou (273686), Federico Carlini (501365), Christophe Picard (501369)   +8 more
core   +1 more source

Presence of an expressed 13-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction [PDF]

, 1994
An expressed beta-tubulin gene (TUBB) has previously been localized to chromosome region 6pter-p21 in man. By using a panel of deletion mutant cell lines and radiation-reduced hybrids containing fragments of chromosome 6, the TUBB locus could be mapped ...
Trowsdale, John, Volz, Armin, Ziegler, Andreas, Weiss, Elisabeth H.   +3 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients

OncoImmunology, 2020
Tumor escape is often associated with abnormalities in the surface expression of the human leukocyte antigen class I (HLA-I) antigens thereby limiting CD8+ cytotoxic T cell responses.
Maria-Filothei Lazaridou, Evamaria Gonschorek, Chiara Massa, Michael Friedrich, Diana Handke, Anja Mueller, Simon Jasinski-Bergner, Reinhard Dummer, Peter Koelblinger, Barbara Seliger   +9 more
doaj   +1 more source

Identification of the Novel HLA-DQB1*06:432 Allele by Sequence-Based Typing

HLA-DQB1*06:432 differs from HLA-DQB1*06:09:01:01 by a nonsynonymous nucleotide substitution in codon 186, changing Valine to ...
John Jeongseok Yang, Heung-Bum Oh
core   +1 more source

A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers [PDF]

, 2012
Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV ...
Stefan Zeuzem, Jörn Lötsch, Doehring, Alexandra, Vermehren, Johannes, Alexandra Doehring, Susser, Simone, Annemarie Berger, Sarrazin, Christoph, Sabine Wicker, Berger, Annemarie, Lötsch, Jörn, Christoph Sarrazin, Johannes Vermehren, Wicker, Sabine, Simone Susser, Zeuzem, Stefan, Berger Annemarie, Doehring Alexandra, Sarrazin Christoph, Lötsch Jörn, Susser Simone, Zeuzem Stefan, Vermehren Johannes, Wicker Sabine   +23 more
core   +2 more sources

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

HLA-KIRs interactions in modulating natural killer cell responses against viral hepatitis: a concise review [PDF]

Exploration of Immunology
Killer immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) molecules play an essential role in regulating immune responses against hepatitis B virus (HBV) and hepatitis C virus (HCV) infections.
Ata Shirizadeh, Amir Mohammad Zargar, Tohid Kazemi, Ghasem Solgi   +3 more
doaj   +1 more source