Results 11 to 20 of about 413,113 (307)

Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]

, 1989
Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Gekeler, V., Müller, C. A., Engler-Blum, G., Steiert, I., Weiss, Elisabeth H., Schmidt, H.   +5 more
core   +1 more source

Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics

Cell Reports, 2021
Summary: The human leukocyte antigen (HLA)-bound viral antigens serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of presented viral antigens ...
Adi Nagler, Shelly Kalaora, Chaya Barbolin, Anastasia Gangaev, Steven L.C. Ketelaars, Michal Alon, Joy Pai, Gil Benedek, Yfat Yahalom-Ronen, Noam Erez, Polina Greenberg, Gal Yagel, Aviyah Peri, Yishai Levin, Ansuman T. Satpathy, Erez Bar-Haim, Nir Paran, Pia Kvistborg, Yardena Samuels   +18 more
doaj   +1 more source

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]

, 1992
An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas, Johnson, Judith P., Ulbrecht, Matthias, Person, Susanne, Weiss, Elisabeth H.   +4 more
core   +1 more source

PECULIARITIES OF HLA-PHENOTYPES IN PATIENTS WITH PYELONEPHRITIS [PDF]

Annals of Mechnikov's Institute, 2016
Introduction. Of great interest are the studies on the role of human leucocyte antigens (HLA) in pathogenesis of a disease. The kidneys is vulnerable to injury in the context of inflammatory responses, with the potential involvement of a number of ...
Haiseniuk F, Driyanska V, Kruglikov V
doaj   +1 more source

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens

Frontiers in Immunology, 2020
Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor
Kyra J. Fuchs, M. Willy Honders, Edith D. van der Meijden, Edith D. van der Meijden, Alwin E. Adriaans, Dyantha I. van der Lee, Margot J. Pont, Margot J. Pont, Ramin Monajemi, Szymon M. Kielbasa, Peter A. C. ’t Hoen, Peter A. C. ’t Hoen, Cornelis A. M. van Bergen, J. H. Frederik Falkenburg, Marieke Griffioen   +14 more
doaj   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Maboko Leonard, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Eller Michael, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +44 more
core   +2 more sources

Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Frontiers in Immunology, 2015
Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome.
Ingrid eSchellens, Ingrid eSchellens, Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Sanne eSpijkers, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Debbie eVan Baarle, Debbie eVan Baarle, Cecile A.C.M. Van Els   +17 more
doaj   +1 more source

HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis. [PDF]

, 2001
Few target epitopes have been described for human CD8 T lymphocytes in antigens of Mycobacterium tuberculosis. By use of a reverse immunogenetics approach, 23 motif-bearing peptides of the Ag85 complex were tested for binding to HLA-B*35, one of the ...
Ogg, GS, Jaye, A, Klein, MR, Lukey, PT, Hammond, AS, King, AS, McAdam, KP, Vekemans, J, Smith, SM   +8 more
core   +1 more source

HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Journal of Immunology Research, 2017
Sensitization to human leukocyte antigens (HLA) in organ transplant patients causes graft rejection, according to the humoral theory of transplantation. Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant ...
Nadim El-Awar, Vadim Jucaud, Anh Nguyen
doaj   +1 more source