Benchmarking freely available HLA typing algorithms across varying genes, coverages and typing resolutions [PDF]
Frontiers in Immunology, 2022 Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is crucial in organ donation, risk assessment of autoimmune and infectious diseases and cancer immunotherapy. However, due to the high genetic polymorphism in this
Nikolas Hallberg Thuesen +5 more
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Extended genomic HLA typing identifies previously unrecognized mismatches in living kidney transplantation [PDF]
Frontiers in Immunology, 2023 IntroductionAntibody mediated rejection (ABMR) is the most common cause of long-term allograft loss in kidney transplantation (KT). Therefore, a low human leukocyte antigen (HLA) mismatch (MM) load is favorable for KT outcomes.
Claudia Lehmann +16 more
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SpecHLA enables full-resolution HLA typing from sequencing data. [PDF]
Cell Rep Methods, 2023 Summary Reconstructing diploid sequences of human leukocyte antigen (HLA) genes, i.e., full-resolution HLA typing, from sequencing data is challenging.
Wang S +5 more
europepmc +2 more sources
Unique Molecular Identifier-Based High-Resolution HLA Typing and Transcript Quantitation Using Long-Read Sequencing. [PDF]
Front Genet, 2022 HLA typing provides essential results for stem cell and solid organ transplants, as well as providing diagnostic benefits for various rheumatology, gastroenterology, neurology, and infectious diseases. It is becoming increasingly clear that understanding
Cornaby C +3 more
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Evaluation of 19 years of international external proficiency testing for high-resolution HLA typing [PDF]
Frontiers in Genetics, 2023 The international high-resolution external proficiency testing (EPT) started in 2004 with high-resolution typing of human leucocyte antigen (HLA) class I (HLA-A,B,C) and HLA class II (HLA-DRB1, DRB345, DQB1, and DPB1) alleles, since possibilities for ...
C. E. M. Voorter +4 more
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Advancements in HLA Typing Techniques and Their Impact on Transplantation Medicine. [PDF]
Med Princ PractHLA typing serves as a standard practice in hematopoietic stem cell transplantation to ensure compatibility between donors and recipients, preventing the occurrence of allograft rejection and graft-versus-host disease.
Geo JA +3 more
europepmc +2 more sources
A long road/read to rapid high-resolution HLA typing: The nanopore perspective. [PDF]
Hum Immunol, 2021 Next-generation sequencing (NGS) has been widely adopted for clinical HLA typing and advanced immunogenetics researches. Current methodologies still face challenges in resolving cis-trans ambiguity involving distant variant positions, and the turnaround ...
Liu C.
europepmc +2 more sources
A Single-Center Experience on HLA Typing with 11 Loci Next Generation Sequencing in Korean Patients with Hematologic Disease [PDF]
Diagnostics, 2022 The human leukocyte antigen (HLA) system comprises the most polymorphic genes of the human genome and is famous for its potential pathological roles. To accurately type HLA genes and find HLA-matched donors, which are critical for effective hematopoietic
Namsoo Kim +3 more
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Clinical applications and methodology updates in HLA typing [PDF]
BMC ImmunologyThe Human Leukocyte Antigen (HLA) system is a key component of the immune system, involving aspects such as autoimmune reactions, transplant rejection reactions, and related diseases.
Kaihao Feng +13 more
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On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes [PDF]
Frontiers in Immunology, 2022 Complete and high-resolution (HR) HLA typing improves the accurate assessment of donor–recipient compatibility and pre-transplant donor-specific antibodies (DSA). However, the value of this information to identify de novo immune-mediated graft events and
Maria Meneghini +23 more
doaj +2 more sources