Results 41 to 50 of about 13,841,936 (288)

Ultrarapid and high-resolution HLA class I typing using transposase-based nanopore sequencing applied in pharmacogenetic testing

Frontiers in Genetics, 2023
Nanopore sequencing has been examined as a method for rapid and high-resolution human leukocyte antigen (HLA) typing in recent years. We aimed to apply ultrarapid nanopore-based HLA typing for HLA class I alleles associated with drug hypersensitivity ...
Nampeung Anukul, Piroon Jenjaroenpun, Piroon Jenjaroenpun, Chonticha Sirikul, Natnicha Wankaew, Natnicha Wankaew, Pattaraporn Nimsamer, Pattaraporn Nimsamer, Ekkapong Roothumnong, Manop Pithukpakorn, Manop Pithukpakorn, Nipapan Leetrakool, Thidathip Wongsurawat, Thidathip Wongsurawat, Thidathip Wongsurawat   +14 more
doaj   +1 more source

Comparison of sequence‐specific oligonucleotide probe vs next generation sequencing for HLA‐A, B, C, DRB1, DRB3/B4/B5, DQA1, DQB1, DPA1, and DPB1 typing: Toward single‐pass high‐resolution HLA typing in support of solid organ and hematopoietic cell transplant programs

HLA, 2019
Many clinical laboratories supporting solid organ transplant programs use multiple HLA genotyping technologies, depending on individual laboratory needs.
Anajane G. Smith, S. Pereira, A. Jaramillo, S. Stoll, F. Khan, N. Berka, A. Mostafa, M. Pando, Crystal Y. Usenko, M. Bettinotti, Chul-woo Pyo, Wyatt C. Nelson, A. Willis, M. Askar, D. Geraghty   +14 more
semanticscholar   +1 more source

HLA DNA Typing and Transplantation [PDF]

Immunity, 2001
PCR-based methods of HLA class I and class II typing have been developed that are simple, rapid, highly informative, and automatable and can be carried out at either intermediate or high levels of allelic resolution in a clinical diagnostic setting as well as for research studies.
Erlich, H.A., Opelz, G., Hansen, J.
openaire   +2 more sources

Impact of human leukocyte antigen mismatch between donor-recipient on acute rejection in liver transplantation using next-generation sequencing: a single-center study

Frontiers in Immunology
BackgroundThe effect of human leukocyte antigen (HLA) mismatch on acute rejection (AR) in liver transplantation (LT) is controversial. This study aimed to investigate the effect of donor-recipient mismatch at the HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5,
Genjie Lu, Yangfang Lu, Yanmin He, Wei Chen, Faming Zhu   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

HLA‐HD: An accurate HLA typing algorithm for next‐generation sequencing data

Human Mutation, 2017
The accurate typing of human leukocyte antigen (HLA) alleles is critical for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system and inflammation‐related disorders, and donor selection in organ ...
S. Kawaguchi, K. Higasa, Masakazu Shimizu, R. Yamada, F. Matsuda   +4 more
semanticscholar   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Assessing the utilization of high‐resolution 2‐field HLA typing in solid organ transplantation

American Journal of Transplantation, 2019
HLA typing in solid organ transplantation (SOT) is necessary for determining HLA‐matching status between donor‐recipient pairs and assessing patients’ anti‐HLA antibody profiles.
Yan-Ping Huang, Anh Dinh, S. Heron, A. Gasiewski, C. Kneib, Hilary Mehler, Michael T. Mignogno, Ryan Morlen, Larissa Slavich, Ethan S. Kentzel, E. Frackelton, J. Duke, D. Ferriola, T. Mosbruger, O. Timofeeva, S. Geier, D. Monos   +16 more
semanticscholar   +1 more source

Science commentary: HLA typing

BMJ, 2001
Human leucocyte antigens (HLAs) are cell surface molecules found on all nucleated cells. Each individual has a unique set of these antigens, half inherited from each parent, and their typing becomes important before organ transplantation. Typing is also used to identify markers for specific diseases, such as HLA B27, which is known to be closely ...
openaire   +3 more sources