Results 61 to 70 of about 13,841,936 (288)
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
HLA-C polymorphisms in two cohorts of donors for bone marrow transplantation
Saudi Journal of Kidney Diseases and Transplantation, 2012 The typing for HLA-C in transplantation was rather neglected in the past. However, several recent studies have emphasized its role in transplantation and its association with the outcome.
Dunia Jawdat +6 more
doaj +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Comparative analyses of the results of HLA genes typing by NGS method using different platforms
Медицинская иммунологияNext generation sequencing (NGS) allows high-resolution and allelic HLA-typing. The most common platform is MiSeq (Illumina, USA). Currently, the maintenance of this device is difficult, which has necessitated the search for analogues that are not ...
I. E. Pavlova +5 more
doaj +1 more source
Evaluation of GenDx Protocol for HLA NGS Genotyping Using the Ion Torrent Sequencing Platform
Acta Medica Bulgarica, 2023 The Human Major Histocompatibility Complex (HLA) is the most polymorphic region of the human genome and encodes molecules with a central role in antigen-specific immune responses.
Ormandjieva A., Ivanova M.
doaj +1 more source
Next-Generation Sequencing Based HLA Typing: Deciphering Immunogenetic Aspects of Sarcoidosis
Frontiers in Genetics, 2018 Unraveling of the HLA-related immunogenetic basis of several immune disorders is complex due to the extensive HLA polymorphism and strong linkage-disequilibrium between HLA loci.
Amit Kishore, M. Petrek
semanticscholar +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Possible association between class- HLA molecules & idiopathic nephrotic syndrome
مجلة كلية الطب, 2007 Background: Nephrotic Syndrome (NS) is a clinical entity having multiple causes, characterized by increased glomeular permeability manifested by massive protein urea with variable Tendency towards edema, hypaalbumineima and hyperlipidemia.
Batool A. Al-Haidary +3 more
doaj
Frontiers in Immunology, 2017 The human leukocyte antigen (HLA) genes code for proteins that play a central role in the function of the immune system by presenting peptide antigens to T cells.
Antti Larjo +6 more
doaj +1 more source