Results 71 to 80 of about 13,841,936 (288)

Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

BMC Bioinformatics, 2018
The adaptive immune response intrinsically depends on hypervariable human leukocyte antigen (HLA) genes. Concomitantly, correct HLA phenotyping is crucial for successful donor-patient matching in organ transplantation.
M. Matey-Hernandez, L. Maretty, J. M. Jensen, Bent O. Petersen, J. Sibbesen, Si-Yang Liu, Palle Villesen, Laurits Skov, Kirstine Belling, C. Have, J. Izarzugaza, M. Grosjean, J. Bork-Jensen, J. Grove, T. Als, Shujia Huang, Yuqi Chang, Ruiqi Xu, Weijian Ye, Jun-Hua Rao, Xiao-Sen Guo, Ji-Hua Sun, Hong-Zhi Cao, Chen Ye, J. van Beusekom, T. Espeseth, E. Flindt, R. M. Friborg, Anders E. Halager, Stéphanie Le Hellard, C. Hultman, F. Lescai, Sheng-Ting Li, O. Lund, Peter Løngreen, T. Mailund, O. Mors, Christian N. S. Pedersen, T. Sicheritz-Pontén, P. Sullivan, Ali Syed, D. Westergaard, Rachita Yadav, Ning Li, Xun Xu, T. Hansen, A. Krogh, L. Bolund, T. Sørensen, O. Pedersen, Ramneek Gupta, Simon Rasmussen, Søren Besenbacher, A. Børglum, Jun Wang, H. Eiberg, K. Kristiansen, M. Schierup, S. Brunak   +58 more
semanticscholar   +1 more source

Unusual HLA Typing in Celiac Disease [PDF]

Disease Markers, 1996
n ...
GRILLO R, PETRONZELLI F, FERRANTE P, MORA B, BONAMICO, Margherita, MAZZILLI, Maria Cristina   +5 more
openaire   +4 more sources

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

مجلة كلية الطب, 2005
Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia .
BATOOL M. MAHDI, salalwa M. Shareef
doaj   +1 more source

Mapping molecular HLA typing data to UNOS antigen equivalents for improved virtual crossmatch

bioRxiv, 2018
Background Virtual crossmatch utilizes HLA typing and antibody screen assay data as a part of organ offers in deceased donor allocation systems. Histocompatibility labs must convert molecular HLA typings to antigen equivalencies for entry into the United
Navchetan Kaur, Evan P. Kransdorf, M. Pando, M. Maiers, B. Ray, J. Lee, P. Lalli, C. Murphey, R. Bray, L. Gragert   +9 more
semanticscholar   +1 more source

Tourette disorder and HLA typing

Yonsei Medical Journal, 1991
HLA A, B, C and DR were typed in 73 Korean patients with Tourette disorder meeting the diagnostic criteria of DSM III-R and compared with 291 normal subjects. Relatively higher frequencies were found in HLA A11 and A26(10) with lower incidences in HLA A24(9) and B13. A family history of tic disorders was associated with a lower frequency of HLA A24(9).
S K, Min, H, Lee, K I, Park, M S, Park, K, Namkoong   +4 more
openaire   +2 more sources

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

A walk through the development of human leukocyte antigen typing: from serologic techniques to next-generation sequencing

Clinical Transplantation and Research
Human leukocyte antigen (HLA) is a group of glycoproteins encoded by the major histocompatibility complex (MHC) that plays a pivotal role in the host's immune defense.
Haeyoun Choi, Eun-Jeong Choi, Hyoung-Jae Kim, In-Cheol Baek, Aegyeong Won, Su Jin Park, Tai-Gyu Kim, Yeun-Jun Chung   +7 more
doaj   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source