Results 21 to 30 of about 13,841,936 (288)

Improvement in HLA-Typing by New Sequence-Specific Oligonucleotides Kits for HLA-A, -B, and -DRB1 Loci

Hla, 2018
Polymerase chain reaction sequence‐specific oligonucleotide is commonly used for HLA‐typing. We replaced our LabType SSO HD (HD) kits with LabType SSO XR (XR) kits (One Lambda, Inc., Canoga Park, California) for HLA‐A, ‐B, and ‐DRB1 following acquisition
Isabelle Jollet, Jonathan Visentin, Charlène Bouthemy   +2 more
exaly   +2 more sources

High-sensitivity HLA typing by Saturated Tiling Capture Sequencing (STC-Seq)

BMC Genomics, 2018
Background Highly polymorphic human leukocyte antigen (HLA) genes are responsible for fine-tuning the adaptive immune system. High-resolution HLA typing is important for the treatment of autoimmune and infectious diseases.
Yang Jiao, Ran Li, Chao Wu, Yibin Ding, Yanning Liu, Danmei Jia, Lifeng Wang, Xiang Xu, Jing Zhu, Min Zheng, Junling Jia   +10 more
doaj   +2 more sources

Application of High-Throughput Next-Generation Sequencing for HLA Typing on Buccal Extracted DNA: Results from over 10,000 Donor Recruitment Samples. [PDF]

PLoS ONE, 2016
Unambiguous HLA typing is important in hematopoietic stem cell transplantation (HSCT), HLA disease association studies, and solid organ transplantation. However, current molecular typing methods only interrogate the antigen recognition site (ARS) of HLA ...
Yuxin Yin, James H Lan, David Nguyen, Nicole Valenzuela, Ping Takemura, Yung-Tsi Bolon, Brianna Springer, Katsuyuki Saito, Ying Zheng, Tim Hague, Agnes Pasztor, Gyorgy Horvath, Krisztina Rigo, Elaine F Reed, Qiuheng Zhang   +14 more
doaj   +2 more sources

Evaluation of HLA typing content of next-generation sequencing datasets from family trios and individuals of arab ethnicity [PDF]

Frontiers in Genetics
Introduction: HLA typing is a critical tool in both clinical and research applications at the individual and population levels. Benchmarking studies have indicated HLA-HD as the preferred tool for accurate and comprehensive HLA allele calling. The advent
Mohammed Dashti, Md Zubbair Malik, Rasheeba Nizam, Sindhu Jacob, Fahd Al-Mulla, Thangavel Alphonse Thanaraj   +5 more
doaj   +2 more sources

Improving HLA typing imputation accuracy and eplet identification with local next‐generation sequencing training data

HLA, 2023
Assessing donor/recipient HLA compatibility at the eplet level requires second field DNA typings but these are not always available. These can be estimated from lower‐resolution data either manually or with computational tools currently relying, at best,
R. Lhotte, V. Letort, C. Usureau, Débora Jorge-Cordeiro, J. Siemowski, Lionel Gabet, P. Cournède, J. Taupin   +7 more
semanticscholar   +1 more source

The Impact of COVID-19 on Healthy Related Issues, A structured Review

مجله كليه طب الكندي, 2021
Coronavirus: (COVID-19) is a recently discovered viral disease caused by a new strain of coronavirus. The majority of patients with corona-virus infections will have a mild-moderate respiratory disease that recovers without special care.
Hiyam Rauof Al-Hamamy
doaj   +1 more source

High resolution HLA-DRB1 analysis and shared molecular amino acid signature of DRβ1 molecules in Occult hepatitis B infection

BMC Immunology, 2022
Aim To investigate the association of human leukocyte antigen (HLA)-DRB1 alleles and the variations of polymorphic amino acid changes in DRβ1 chain in Shaanxi Han population with Occult hepatitis B infection (OBI).
Tianju Wang, Chunmei Shen, Hengxin Li, Liping Chen, Sheng Liu, Jun Qi   +5 more
doaj   +1 more source

Development of a high-resolution mass-spectrometry-based method and software for human leukocyte antigen typing

Frontiers in Immunology, 2023
IntroductionThe human leukocyte antigen (HLA) system plays a critical role in the human immune system and is strongly associated with immune recognition and rejection in organ transplantation.
Kun Wang, Zetao Sun, Fei Zhu, Yunping Xu, Feng Zhou   +4 more
doaj   +1 more source

Diagnosis of COVID-19: facts and challenges

New Microbes and New Infections, 2020
At the end of 2019, the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China, then spread rapidly across the country and throughout the world.
H.H. Zalzala
doaj   +1 more source

HLA typing from 1000 genomes whole genome and whole exome illumina data. [PDF]

PLoS ONE, 2013
Specific HLA genotypes are known to be linked to either resistance or susceptibility to certain diseases or sensitivity to certain drugs. In addition, high accuracy HLA typing is crucial for organ and bone marrow transplantation. The most widespread high
Endre Major, Krisztina Rigó, Tim Hague, Attila Bérces, Szilveszter Juhos   +4 more
doaj   +1 more source