Results 31 to 40 of about 13,841,936 (288)

SOAPTyping: an open-source and cross-platform tool for sequence-based typing for HLA class I and II alleles

BMC Bioinformatics, 2020
Background The human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial in many biomedical and clinical settings.
Yong Zhang, Yongsheng Chen, Huixin Xu, Junbin Fang, Zijian Zhao, Weipeng Hu, Xiaoqin Yang, Jia Ye, Yun Cheng, Jiayin Wang, Weiqiang Sun, Jian Wang, Huanming Yang, Jing Yan, Lin Fang   +14 more
doaj   +1 more source

Substituting imputation of HLA antigens for high‐resolution HLA typing: Evaluation of a multiethnic population and implications for clinical decision making in transplantation

American Journal of Transplantation, 2020
Molecular mismatch analysis for assessment of histocompatibility in transplantation requires high‐resolution HLA typing. Algorithms to “guesstimate” high‐resolution from low‐resolution typing exist, but their accuracy remains unknown.
Rachel M. Engen, Aneta M. Jedraszko, M. Conciatori, A. Tambur   +3 more
semanticscholar   +1 more source

Measuring ambiguity in HLA typing methods. [PDF]

PLoS ONE, 2012
In hematopoietic stem cell transplantation, donor selection is based primarily on matching donor and patient HLA genes. These genes are highly polymorphic and their typing can result in exact allele assignment at each gene (the resolution at which ...
Vanja Paunić, Loren Gragert, Abeer Madbouly, John Freeman, Martin Maiers   +4 more
doaj   +1 more source

Rapid, highly accurate and cost‐effective open‐source simultaneous complete HLA typing and phasing of class I and II alleles using nanopore sequencing

HLA, 2020
Accurate rapid genotyping of the genes within the HLA region presents many difficulties because of the complexity of this region. Here we present the results of our proof of concept nanopore‐based long read polymerase chain reaction (PCR) solution for ...
J. Stockton, T. Nieto, Elizabeth Wroe, A. Poles, N. Inston, D. Briggs, A. Beggs   +6 more
semanticscholar   +1 more source

Benchmarking the Human Leukocyte Antigen Typing Performance of Three Assays and Seven Next-Generation Sequencing-Based Algorithms

Frontiers in Immunology, 2021
With the great progress made recently in next generation sequencing (NGS) technology, sequencing accuracy and throughput have increased, while the cost for data has decreased.
Ping Liu, Minya Yao, Yu Gong, Yunjie Song, Yanan Chen, Yizhou Ye, Xiao Liu, Fugen Li, Hua Dong, Rui Meng, Hao Chen, Aiwen Zheng, Aiwen Zheng   +12 more
doaj   +1 more source

High-Resolution HLA Typing of HLA-A, -B, -C, -DRB1, and -DQB1 in Kinh Vietnamese by Using Next-Generation Sequencing

Frontiers in Genetics, 2020
Human leukocyte antigen (HLA) genotyping displays the particular characteristics of HLA alleles and haplotype frequencies in each population. Although it is considered the current gold standard for HLA typing, high-resolution sequence-based HLA typing is
M. Do, L. G. H. Le, V. Nguyen, Dang Ngoc Tran, Nghia Hoai Nguyen, H. A. Vu, T. Mai   +6 more
semanticscholar   +1 more source

A glow of HLA typing in organ transplantation

Clinical and Translational Medicine, 2013
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune ...
Batool Mutar Mahdi
doaj   +1 more source

Super high-resolution single-molecule sequence-based typing of HLA class I alleles in HIV-1 infected individuals in Ghana

PLoS ONE, 2022
Polymorphisms in human leukocyte antigen (HLA) class I loci are known to have a great impact on disease progression in HIV-1 infection. Prevailing HIV-1 subtypes and HLA genotype distribution are different all over the world, and the HIV-1 and host HLA ...
Nicholas I. Nii-Trebi, Saori Matsuoka, Ai Kawana-Tachikawa, Evelyn Y. Bonney, Christopher Z. Abana, Sampson B. Ofori, Taketoshi Mizutani, Aya Ishizaka, Teiichiro Shiino, Jun Ohashi, Taeko K. Naruse, Akinori Kimura, Hiroshi Kiyono, Koichi Ishikawa, William K. Ampofo, Tetsuro Matano   +15 more
doaj   +2 more sources

HLA typing in systemic sclerosis

Reumatismo, 2011
OBJECTIVE: The aim of the study was to investigate the relationship between Systemic Sclerosis (SSc) and HLA antigens, and to correlate these antigens with the clinical manifestations of the disease. MATERIALS AND METHODS: 55 patients were stratified according a) to the cutaneous involvement b) to the positivity of Scl-70 and anticentromere antibody ...
E. Favalli, F. Ingegnoli, S. Zeni, M. Faré, F. Fantini   +4 more
openaire   +5 more sources

Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study.

Biology of Blood and Marrow Transplantation, 2019
HLA matching at an allelic-level resolution for volunteer unrelated donor (VUD) hematopoietic cell transplantation (HCT) results in improved survival and fewer post-transplant complications.
N. Mayor, J. Hayhurst, T. Turner, Richard Szydlo, B. Shaw, Will P. Bultitude, Jex-Ray Sayno, F. Tavarozzi, K. Latham, C. Anthias, J. Robinson, Henny Braund, R. Danby, J. Perry, M. Wilson, A. Bloor, I. McQuaker, S. Mackinnon, D. Marks, A. Pagliuca, M. Potter, V. Potter, N. Russell, K. Thomson, J. Madrigal, S. Marsh   +25 more
semanticscholar   +1 more source