Results 231 to 240 of about 191,208 (362)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci. [PDF]

Front Immunol
Fujita Y, Yoshihara K, Takahashi D, Tanaka H, Kino Y, Yamagata F, Samori M, Takahashi S, Yoshihara S.   +8 more
europepmc   +1 more source

HLA-DR15 Antigen [PDF]

, 2020
openaire   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

T Cell Receptor Sharing in Hypersensitivity Pneumonitis. [PDF]

Comput Struct Biotechnol J
Sendama W, Funston W, Davidson RCH, Rostron AJ, Simpson AJ.   +4 more
europepmc   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of <i>Mycobacterium tuberculosis</i> antigens. [PDF]

Elife
Kim SJ, Peterson JC, Olive AJ, Tafesse FG, Kulicke CA, Karamooz E, Lewinsohn D.   +6 more
europepmc   +1 more source

HLA-DP Antigen [PDF]

, 2020
openaire   +1 more source

EFFECT OF MINOR HISTOCOMPATIBILITY ANTIGEN INCOMPATIBILITIES IN ALLOGENEIC STEM CELL TRANSPLANTATION FROM HLA-IDENTICAL DONORS

, 2003
H Sato, Shizuka Kondo, Rumi Kato, Shizuka Yasue, Shinji Nakao, Shintaro Shiobara   +5 more
openalex   +2 more sources

Associations between residential greenness, land cover and risk of celiac disease in genetically at‐risk children: Celiac Prediction in Skåne study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Our aim was to study the association between residential land cover and greenness during childhood and risk of developing celiac disease (CeD). Methods The Celiac Prediction in Skåne study prospectively followed 5969 human leukocyte antigen (HLA)‐genotyped children born 2001–2004 who were screened for CeD at ages 3, 9, and 15 years ...
Michaela Boström, Marja I. Roslund, Lauri Häme, Juulia Manninen, Matthieu Molinier, Aki Sinkkonen, Daniel Agardh   +6 more
wiley   +1 more source