Results 291 to 300 of about 191,208 (362)

Novel Progress in Limbal Stem Cell Transplantation

Organ Medicine, EarlyView.
Liqin Huang, Liangbo Chen
wiley   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Optimisation and application of a T-cell antigen-specific activation assay as diagnostic and treatment-monitoring tool for tuberculosis. [PDF]

ERJ Open Res
Musvosvi M, Nemes E, Tameris M, Mendelsohn SC, Fisher M, Filander E, Visagie S, Africa H, Jaxa L, Mulenga H, Veldsman A, Hatherill M, Riou C, Via LE, Malherbe ST, Walzl G, Chen RY, Barry CE, Wilkinson RJ, Scriba TJ.   +19 more
europepmc   +1 more source

Investigation of Human Leukocyte Antigen (HLA) Class I and II Alleles and Hepatitis C Virus (HCV) Genotypes in Patients Infected with HCV

, 2018
Abeer A. Sharaf, Maha S. Kawashti, Naglaa F. Abd El Haliem, Hawazen Ismaeel   +3 more
openalex   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Neutrophil-reactive autoantibodies in blood donors: Can we expect TRALI? [PDF]

Transfusion
Jehle S, Preuss D, Waxmann Y, Spies-Naumann A, Schmidt S, Kapur R, Sachs UJ, Bayat B.   +7 more
europepmc   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Preclinical Assessment of HLA-A*02:01-Restricted PSMA and STEAP1 Epitopes for Peptide-Based Immunotherapy in Prostate Cancer. [PDF]

Drug Des Devel Ther
Huang Y, Yang Y, Xie Y, Shu Y, Yang S, Long X, Wen Z, Duan X, Fu L, Gu D, Huang T.   +10 more
europepmc   +1 more source

HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors. [PDF]

Sci Adv
Hwang D, Erdman MC, Adhikari S, Pantula R, Epstein K, Li P, Costabile F, Rotsides P, Wang CS, Sun SM, Fazelinia H, Spruce LA, Fugmann T, Rrustemi T, Soh WT, Farrel A, Want MY, Facciabene A, Mir M, Maris JM, Sgourakis NG.   +20 more
europepmc   +1 more source