Results 101 to 110 of about 45,099 (293)

High-Mobility Group Box 1-Mediated Matrix Metalloproteinase-9 Expression in Non-Small Cell Lung Cancer Contributes to Tumor Cell Invasiveness [PDF]

, 2011
High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions. It is involved in invasion and metastasis in various human malignancies.
LIU, PO-LEN;CHOU, SHAH-HWA;LIN, FENG-YEN;CHEN, YUH-LIEN;CHEN, WEN-CHI;CHEN, YUNG-HSIANG;CHONG, INN-WEN, 劉博侖;周世華;林豐彥;陳玉怜;陳汶吉;陳永祥;鍾飲文   +1 more
core  

Functional diversity of non-histone chromosomal protein hmgb1 [PDF]

, 2021
The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin.
Chikhirzhina E.
core  

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo [PDF]

, 2017
Shuang Jiang, Xiaolong Chen Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China Background: Diabetic retinopathy (DR), one of the most common complications of late-phase diabetes, is associated with many risk ...
Jiang S, Chen X
core  

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

LSS induced HMGB1 translocation and release and upregulated protein expression and inflammatory cytokines secretion in HUVECs. [PDF]

, 2015
After HUVECs were stimulated by LSS, HMGB1 content in supernatant and HMGB1 translocation were determined by ELISA and immunoflurescence, respectively. PECAM-1 and PARP-1 protein expression were determined by western blot analysis.
Jian-ning Zhang (707863), Gui-xia Wang (707862), Wei-dong Qin (707860), Shao-hua Mi (707861), Yang Ma (214907), Mingxiang Zhang (126631), Chen Li (54018), Hao Wang (39217), Fan Zhang (46132), Da-wei Wu (707864)   +9 more
core   +1 more source

Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration

Cell Communication and Signaling
Post-translational modifications (PTMs) of the non-histone protein high-mobility group protein B1 (HMGB1) are involved in modulating inflammation and immune responses.
Xiaole Meng, Risi Na, Xiao Peng, Hui Li, Wanxin Ouyang, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Huamei Tang, Guohong Zhuang, Zhihai Peng   +14 more
doaj   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes

Mediators of Inflammation, 2016
High mobility group box 1 protein (HMGB1) is a molecule related to the development of inflammation. Autophagy is vital to maintain cellular homeostasis and protect against inflammation of adipocyte injury.
Huanhuan Feng, Lili Yu, Guojun Zhang, Guoyan Liu, Can Yang, Hui Wang, Xiangfeng Song   +6 more
doaj   +1 more source