Results 111 to 120 of about 45,099 (293)

High Mobility Group Box 1 Regulates Uterine Decidualization through Bone Morphogenetic Protein 2 and Plays a Role in Kruppel-Like Factor 5-Induced Stromal Differentiation

Cellular Physiology and Biochemistry, 2018
Background/Aims: High mobility group box 1 (Hmgb1) is associated with a variety of physiological processes including embryonic development, cell proliferation and differentiation, but little information is available regarding its biological role in ...
Kai Wang, Zhan-Qing Yang, Hai-Fan Yu, Yu-Si Wang, Bin Guo, Zhan-Peng Yue   +5 more
doaj   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

POTENTIAL BIOMARKER FOR EPILEPSY: HIGH-MOBILITY GROUP BOX 1 PROTEIN (HMGB1) [PDF]

, 2023
High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein that is generated by glia and neurons in response to inflammasome activation, activating the target cells' RAGE and TLR4 receptors for advanced glycation end products.One of the ...
Azamat qizi, Sultonova Dilbar, R. B., Azizova   +1 more
core  

Cisplatin Dependent Secretion of Immunomodulatory High Mobility Group Box 1 (HMGB1) Protein from Lung Cancer Cells. [PDF]

Biomolecules, 2023
Gillespie KP, Pirnie R, Mesaros C, Blair IA.   +3 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

The DNA architectural protein HMGB1 facilitates RTA-mediated viral gene expression in gamma-2 herpesviruses [PDF]

, 2004
Replication and transcription activator (RTA), an immediate-early gene product of gamma-2 herpesviruses including Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gamma herpesvirus 68 (MHV-68), plays a critical role in controlling the viral life
Sun, Ren, Martinez-Guzman, Dee Ann, Johnson, Reid C., Hwang, Seungmin, Wong, Ben, Wong, Wendy, Round, June, Liang, Jie, Moon, Jung Song, Turpaz, Yaron, Carey, Michael   +10 more
core   +1 more source

DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein. [PDF]

J Biol Chem, 2022
Wang X, Mayorga-Flores M, Bien KG, Bailey AO, Iwahara J.   +4 more
europepmc   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Targeted quantitation of HMGB1 protein by label-free Mass Spectrometry technique [PDF]

, 2015
— Mass spectrometry (MS)-based methods have become popular in recent years for the quantitation of biomolecules, especially peptides and proteins. High Mobility Group Box-1 protein (HMGB1) is a nuclear DNA-binding protein that resides inside the ...
Mauro Patrone, SASSI, MARIA PAOLA, Maria Paola Sassi, Emilio Marengo, Simona Martinotti, Martinotti, Simona, Manfredi, Marcello, Patrone, Mauro, Ranzato, Elia, Marengo, Emilio, Elia Ranzato, Marcello Manfredi   +11 more
core   +1 more source