Results 171 to 180 of about 41,752 (255)

Screening and Targeting the HMGB1/RAGE Axis via Proteomics to Alleviate Inflammatory Responses in a <i>Pseudomonas aeruginosa</i>-Induced Rat Model of VAP. [PDF]

J Inflamm Res
Huang X, Feng M, Li S, Huang C, Xu Y, Cheng H, Mi L, Wang H.   +7 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

HMGB1 regulates mitochondrial structure and reactive oxygen species balance during the transition from naïve to primed pluripotency. [PDF]

Front Cell Dev Biol
Starkova TY, Ponomartsev SV, Fishman VS, Battulin NR, Aksenov ND, Bakhmet EI, Kuzmin AA, Bogolyubov DS, Sinenko SA, Tomilin AN.   +9 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

High Mobility Group Protein B1 Promotes Interferon Regulatory Factor 1 SUMOylation to Prime Trained Immunity of Circulating Monocytes and Aggravate the Progressive Synovial Inflammation in Knee Osteoarthritis. [PDF]

Research (Wash D C)
Jie L, Mao J, Zhang L, Fu H, Li X, Liao T, Wei Y, Liu D, Du J, Wu P, Yin S, Zhang N, Cao M, Wang P.   +13 more
europepmc   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

IL‑17A⁺ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia. [PDF]

Int J Mol Med
Zhang MX, Tang JF, Hong M, Yang Y, Zhou Y, Chi SQ, Rong LY, Cao GQ, Zhang X, Zhang JX, Tang ST.   +10 more
europepmc   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Picropodophyllotoxin Mitigates Severe Inflammation Through HMGB1 Inhibition. [PDF]

Biomolecules
Han G, Kim GE, Bae JS.
europepmc   +1 more source