Results 161 to 170 of about 41,752 (255)

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study. [PDF]

Einstein (Sao Paulo)
Vesco BCD, Miranda AC, Stefani FDC, Morello LG, Zanette DL, Ferreira LEN, Menezes IAC.   +6 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

CRISPLD2 protects against liver inflammation and fibrosis via GRP78 to repress HMGB1/TLR4 axis-mediated STING palmitoylation. [PDF]

Hepatol Commun
Zhang H, Wang J, Yang H, Yan Y, Zou J, Liu Z.   +5 more
europepmc   +1 more source

Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence

Journal of Periodontal Research, EarlyView.
Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno, Pablo Galindo‐Fernandez, Allinson Olaechea, Francisco O'Valle, Abdusalam E. Alrmali, Hom‐Lay Wang, Miguel Padial‐Molina   +6 more
wiley   +1 more source

Immunohistochemical Evaluation of TLR‐4, HSP‐70 and Caspase‐3 Expressions in Lesional Areas of Ecthyma Disease

Veterinary Dermatology, EarlyView.
Background: Contagious ecthyma (Orf) is a highly contagious, economically significant disease affecting sheep, goats and wild small ruminants, caused by the resilient Orf virus (ORFV). It produces thick, crusted lesions around the mouth and nostrils, especially in animals aged 3–4 months, sometimes causing near 100% mortality in immunocompromised young
Emine Nur Dincer, Ozlem Ozmen
wiley   +1 more source

HMGB1-mediated formation of IL-33-abundant NETs drives lung-to-kidney injury in severe pneumonia-associated acute kidney injury. [PDF]

JCI Insight
Ma M, Zhang H, Deng W, Du X, Chen M, Chen D, Pan B, Wang Z, Chen T, Chen C, Wan X, Cao C.   +11 more
europepmc   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Timing‐dependent protective and therapeutic effects of ethyl pyruvate in trinitrobenzene sulfonic acid‐induced experimental colitis

Experimental Physiology, EarlyView.
Abstract Ulcerative colitis (UC) involves excessive inflammation, extracellular matrix remodelling and oxidative stress. Ethyl pyruvate (EP) exhibits anti‐inflammatory effects, but the comparative efficacy of prophylactic versus therapeutic administration and timing‐dependent molecular responses remains unclear.
Hatice Yorulmaz, Elif Yorulmaz, Elif Özkök, Suat Hayri Küçük, Erdem Sünger, Ayyub Ebrahimi, Beyza Yılmaz, Serdar Altınay   +7 more
wiley   +1 more source